Evidence map›Paper›PMID 37520418›Full record

ArticleOpen forum infectious diseases2023

Differential Effects of Antimalarial Drugs on Parasite Clearance Rates Are Reflected by

Alexuse M Saidi, Bo Zhang, Melody Jiang, Kondwani Kawaza, Janelisa Musaya, Terrie Taylor, Karl Seydel

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Alexuse M SaidiBlantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.
Bo ZhangVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-4381-1124
Melody JiangDepartment of Statistics, University of Washington, Seattle, Washington, USA.
Kondwani KawazaDepartments of Paediatrics and Child Health, Queen Elizabeth Central Hospital, Kamuzu University of Health Sciences, Blantyre, Malawi.
Janelisa MusayaThe Malawi Liverpool Wellcome Trust Clinical Research Program, Queen Elizabeth Central Hospital, Kamuzu University of Health Sciences, Blantyre, Malawi.
Terrie TaylorBlantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.
Karl SeydelBlantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.ORCID https://orcid.org/0000-0001-9859-9549
Kamuzu University of Health SciencesFred Hutch Cancer Center · USQueen Elizabeth Central Hospital · MWUniversity of Liverpool · GBUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The location of Methods: Ring ratios were calculated for 400 hospitalized children with CM in Blantyre, Malawi between 2010 and 2019 (quinine: 2010-2013, artesunate: 2014-2019). Results: In both treatment groups, parasite clearance rates were positively associated with the ring ratios, with a stronger association in the artesunate era than the quinine era. In the quinine era, an increase of 1-unit log Conclusions: This analysis provides in vivo evidence supporting the hypothesis that more rapid parasite clearance rates in artesunate recipients are due to its superiority over quinine in killing ring-stage parasites.

Indexed as

artesunatecerebral malariaPlasmodium falciparum histidine-rich protein 2quininering ratio

Identifiers

PMID37520418
PMCPMC10375422
OpenAlexW4384704763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.