Evidence map›Paper›PMID 37520369›Full record

ArticleFrontiers in microbiology2023

TRIM3 attenuates cytokine storm caused by

Ke Jin, Yan Dai, Ke Ouyang, Huaying Huang, Zhengyi Jiang, Zhan Yang, Tingting Zhou, Hong Lin, Chunhui Wang, Chunyan Wang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Ke Jin *Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yan Dai *Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ke OuyangDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huaying HuangDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhengyi JiangDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhan YangEpidemiological Department, Huadong Medical Institute of Biotechniques, Nanjing, China.
Tingting ZhouEpidemiological Department, Huadong Medical Institute of Biotechniques, Nanjing, China.
Hong LinDepartment of Transfusion Research, Jiangsu Province Blood Center, Nanjing, China.
Chunhui WangEpidemiological Department, Huadong Medical Institute of Biotechniques, Nanjing, China.
Chunyan WangEpidemiological Department, Huadong Medical Institute of Biotechniques, Nanjing, China.
Xuewei SunSchool of Basic Medicine, Binzhou Medical University, Yantai, China.
Dafeng LuSchool of Public Health, Nanjing Medical University, Nanjing, China.
Xiaoguang LiuDepartment of Respiratory and Critical Care Medicine, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.
Nannan HuDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chuanlong ZhuDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jin ZhuEpidemiological Department, Huadong Medical Institute of Biotechniques, Nanjing, China.
Jun LiDepartment of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiangsu Province Hospital · CNNanjing Medical University · CNHuadong Hospital · CNHuadong Medical Institute of BiotechniquesBinzhou University · CNJiangsu Province Blood Center · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by the Methods: TRIM3 mRNA levels were detected in PBMCs between 29 SFTS patients and 29 healthy controls by qRT-PCR. We established the pathogenic IFNAR Results: Compared to healthy controls, TRIM3 mRNA expression in PBMCs is decreased in SFTS patients, especially in severe cases. TRIM3 mRNA and protein were synchronously reduced in the livers, spleens, lungs, and kidney tissues of the IFNAR Conclusion: TRIM3 can inhibit the production of cytokines by regulating the degradation of TLR3 through K48-linked ubiquitination, which can be a therapeutic target for improving the prognosis of SFTS.

Indexed as

cytokine stormDabie bandavirussevere fever with thrombocytopenia syndromeToll-like receptor 3TRIM3

Identifiers

PMID37520369
PMCPMC10375709
OpenAlexW4384276705

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.