Evidence map›Paper›PMID 37520138›Full record

ReviewStructural heart : the journal of the Heart Team2023

Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement.

Mina Iskander, Yasser Jamil, John K Forrest, Mahesh V Madhavan, Raj Makkar, Martin B Leon, Alexandra Lansky, Yousif Ahmad

Open access · goldAbstract readReview
In one paragraph

Review in Structural heart : the journal of the Heart Team, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mina IskanderYale School of Medicine, Yale University, New Haven, Connecticut, USA.
Yasser JamilYale School of Medicine, Yale University, New Haven, Connecticut, USA.
John K ForrestYale School of Medicine, Yale University, New Haven, Connecticut, USA.
Mahesh V MadhavanColumbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York, USA.
Raj MakkarSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Martin B LeonColumbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York, USA.
Alexandra LanskyYale School of Medicine, Yale University, New Haven, Connecticut, USA.
Yousif AhmadYale School of Medicine, Yale University, New Haven, Connecticut, USA.
Yale University · USNewYork–Presbyterian Hospital · USCedars-Sinai Medical Center · USMedical College of Wisconsin · USQueen Mary University of London · GB

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Transcatheter aortic valve replacement (TAVR) is a treatment option for patients with symptomatic severe aortic stenosis across the entire spectrum of surgical risk. Recent trial data have led to the expansion of TAVR into lower-risk patients. With iterative technological advances and successive increases in procedural experience, the occurrence of complications following TAVR has declined. One of the most feared complications remains stroke, and patients consider stroke a worse outcome than death. There has therefore been great interest in strategies to mitigate the risk of stroke in patients undergoing TAVR. In this paper, we will discuss mechanisms and predictors of stroke after TAVR and describe the currently available cerebral embolic protection devices, including their design and relevant clinical studies pertaining to their use. We will also review the current overall evidence base for cerebral embolic protection during TAVR and ongoing randomized controlled trials. Finally, we will discuss our pragmatic recommendations for the use of cerebral embolic protection devices in patients undergoing TAVR.

Indexed as

Aortic stenosisCerebral protectionStrokeTAVR

Identifiers

PMID37520138
PMCPMC10382985
OpenAlexW4366144496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.