Evidence map›Paper›PMID 37520119›Full record

ArticleJournal of toxicology2023

Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of

Gérard Bessan Dossou-Agoin, Maxime Machioud Sangaré-Oumar, Téniola Isabelle Sacramento, Mariette Sindété, Egnon Jacques Hougbénou-Houngla, Nounagnon Darius Tossavi, Simon Azonbakin, Adam Gbankoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gérard Bessan Dossou-AgoinExperimental Physiology and Pharmacology Laboratory, Faculty of Sciences and Technology, University of Abomey-Calavi, Abomey-Calavi, Benin.ORCID https://orcid.org/0000-0002-8941-0991
Maxime Machioud Sangaré-OumarExperimental Physiology and Pharmacology Laboratory, Faculty of Sciences and Technology, University of Abomey-Calavi, Abomey-Calavi, Benin.
Téniola Isabelle SacramentoSchool of Management and Operation of Livestock Systems, National University of Agriculture, Ketou, Benin.
Mariette SindétéExperimental Physiology and Pharmacology Laboratory, Faculty of Sciences and Technology, University of Abomey-Calavi, Abomey-Calavi, Benin.ORCID https://orcid.org/0000-0003-2075-6318
Egnon Jacques Hougbénou-HounglaExperimental Physiology and Pharmacology Laboratory, Faculty of Sciences and Technology, University of Abomey-Calavi, Abomey-Calavi, Benin.
Nounagnon Darius TossaviExperimental Physiology and Pharmacology Laboratory, Faculty of Sciences and Technology, University of Abomey-Calavi, Abomey-Calavi, Benin.
Simon AzonbakinHistology, Biology of Reproduction, Cytogenetics and Medical Genetics Laboratory, Faculty of Health Sciences, University of Abomey-Calavi, Abomey-Calavi, Benin.
Adam GbankotoExperimental Physiology and Pharmacology Laboratory, Faculty of Sciences and Technology, University of Abomey-Calavi, Abomey-Calavi, Benin.ORCID https://orcid.org/0000-0001-5114-2090
Université d'Abomey-Calavi · BJUniversité d'Agriculture de Kétou · BJ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objective: This study was carried out to assess the acute and repeated dose 28-day oral toxicity of the aqueous extracts from Methods: The acute toxicity test was performed according to the line 423 of the Organization for Economic Cooperation and Development (OECD) guidelines. The rats were randomly divided into three groups ( Results: In the acute oral toxicity test, there was no morbidity or mortality related to the treatments. Both extracts belong therefore to category 5 of the globally harmonized system (GHS) of classification. In the repeated dose 28-day oral toxicity test, both extracts did not alter animal's behavior. However, both extract administration led to proteinuria and renal damages. Conclusion:

Identifiers

PMID37520119
PMCPMC10382242
OpenAlexW4384942554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.