Evidence map›Paper›PMID 37519908›Full record

ArticleRegenerative therapy2023

Volatile organic compounds and ionic substances contamination in cell processing facilities during rest period; a preliminary assessment of exposure to cell processing operators.

Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Keiichi Yano, Yukiko Ota, Kengo Tomita, Naoki Kagi, Ichiro Sekiya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mitsuru MizunoCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), 1-5-45, Bunkyo-ku, Yushima, Tokyo 113-8519, Japan.
Koki AbeMedical Environment Engineering Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation, 3-4-17, Koto-ku, Etchūjima, Tokyo, 135-0044, Japan.
Takashi KakimotoMedical Environment Engineering Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation, 3-4-17, Koto-ku, Etchūjima, Tokyo, 135-0044, Japan.
Keiichi YanoMedical Environment Engineering Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation, 3-4-17, Koto-ku, Etchūjima, Tokyo, 135-0044, Japan.
Yukiko OtaMedical Environment Engineering Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation, 3-4-17, Koto-ku, Etchūjima, Tokyo, 135-0044, Japan.
Kengo TomitaMedical Environment Engineering Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation, 3-4-17, Koto-ku, Etchūjima, Tokyo, 135-0044, Japan.
Naoki KagiDepartment of Architecture and Building Engineering, School of Environment and Society, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-ku, Tokyo, 152-8552, Japan.
Ichiro SekiyaCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), 1-5-45, Bunkyo-ku, Yushima, Tokyo 113-8519, Japan.
Shimizu (Japan) · JPTokyo Medical and Dental University · JPTokyo Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cell processing operators (CPOs) use a variety of disinfectants that vaporize in the workspace environment. These disinfectants can induce allergic reactions in CPOs, due to their long working hours at cell processing facilities (CPFs). Ionic substances such as CH Methods: Sampling was conducted at three CPFs: two located in medical institutions and one located at a different institution. Air samples were collected using a flow pump. Ion chromatographic analysis of the anionic and cationic compounds was performed. For VOC analysis, a thermal desorption analyzer coupled with capillary gas chromatograph and flame ionization detector was used. Results: Analysis of the ionic substances showed that Cl Conclusions: No VOCs or ionic substances of immediate concern to the health of the CPOs were detected during the non-operating period. However, new clinical trials of cell products are currently underway in Japan, and a variety of new cell products are expected to be approved. With an increase in cell processing, health risks to CPOs that have not been considered previously, may become apparent. We should continue to prepare for the future expansion of the industry using a scientific approach to collect various pieces of information and make it publicly available to build a database.

Indexed as

Air qualityCell processing operatorsDisinfectant odorExposure assessmentIonic substancesVolatile organic compounds (VOCs)

Identifiers

PMID37519908
PMCPMC10371781
OpenAlexW4385406749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.