Evidence map›Paper›PMID 37519876›Full record

ArticleBiomedical engineering letters2023

Histologic evaluation of a catheter coated with paclitaxel PLGA nanoparticles in the internal jugular veins of rats.

Song-Yi Kim, Susmita Aryal, Wan Su Yun, Woo Cheol Kim, Suk-Bae Moon, Gi-Bong Chae, Jaehong Key, Seongyup Kim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical engineering letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Song-Yi KimDepartment of Surgery, Chungnam National University Sejong Hospital, Sejong, Korea.
Susmita AryalDepartment of Biomedical Engineering, Yonsei University, Wonju, Korea.
Wan Su YunDepartment of Biomedical Engineering, Yonsei University, Wonju, Korea.
Woo Cheol KimDepartment of Biomedical Engineering, Yonsei University, Wonju, Korea.
Suk-Bae MoonDepartment of Surgery, College of Medicine, Kangwon National University, Chun-Cheon, Korea.
Gi-Bong ChaeDepartment of Surgery, College of Medicine, Kangwon National University, Chun-Cheon, Korea.
Jaehong KeyDepartment of Biomedical Engineering, Yonsei University, Wonju, Korea.
Seongyup KimDepartment of Surgery, College of Medicine, Yonsei University, Wonju, Korea.
Yonsei University · KRKangwon National University · KRChungnam National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to investigate the potential impact of catheterization on intimal hyperplasia and explore the efficacy of Paclitaxel loaded PLGA nanoparticles (PTX-NPs) in preventing stenosis at the site of venous injury. Under general anesthesia, Central Venous Catheters were inserted into the rat's right internal jugular veins (IJV) using the cut-down technique. Twenty bare catheters (C) and twenty PTX-NPs coated catheters (P) were assigned to one of four groups (C2, C4, P2, or P4) based on catheter type and expected survival time. 2 or 4 weeks after surgery, IJVs were completely harvested by formalin fixation and gelatin infusion and slides were stained with H&E (Haematoxylin and Eosin) and Masson's technique. The P2 (Paclitaxel coating, 2 weeks) group showed the most proliferation among the four groups and the P4 (Paclitaxel coating, 4 weeks) showed a tendency to decrease proliferation. Additionally, the lumen size in the P4 group was about 6% smaller than in the P2 group, and there was a lower prevalence of stenotic grade in the P4 group. Our study suggests that PTX-NPs coated catheters may be effective in preventing venous stenosis if the intended usage is prolonged, rather than for a short-term period. Graphical abstract: Schematic representation of catheter functionalization and coating of PTX-NPs on Catheter. Supplementary Information: The online version contains supplementary material available at 10.1007/s13534-023-00282-y.

Indexed as

Central venous cathetersIntimal hyperplasiaNanoparticlesNeointimaPaclitaxelStenosis

Identifiers

PMID37519876
PMCPMC10382362
OpenAlexW4367369022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.