Evidence map›Paper›PMID 37519829›Full record

ArticleEuropean journal of medicinal chemistry reports2022

Investigating novel thiazolyl-indazole derivatives as scaffolds for SARS-CoV-2 M

Justin Airas, Catherine A Bayas, Abdellah N'Ait Ousidi, Moulay Youssef Ait Itto, Aziz Auhmani, Mohamed Loubidi, M'hamed Esseffar, Julie A Pollock, Carol A Parish

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Scaling Graph Neural Networks to Large Proteins.Journal of chemical theory and computation · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Justin AirasDepartment of Chemistry, University of Richmond, Gottwald Center for the Sciences, Richmond, VA, 23173, USA.
Catherine A BayasDepartment of Chemistry, University of Richmond, Gottwald Center for the Sciences, Richmond, VA, 23173, USA.
Abdellah N'Ait OusidiDépartement de Chimie, Faculté des Sciences Semlalia, Cadi Ayyad University, BP, 2390, Marrakech, Morocco.
Moulay Youssef Ait IttoDépartement de Chimie, Faculté des Sciences Semlalia, Cadi Ayyad University, BP, 2390, Marrakech, Morocco.
Aziz AuhmaniDépartement de Chimie, Faculté des Sciences Semlalia, Cadi Ayyad University, BP, 2390, Marrakech, Morocco.
Mohamed LoubidiDépartement de Chimie, Faculté des Sciences Semlalia, Cadi Ayyad University, BP, 2390, Marrakech, Morocco.
M'hamed EsseffarDépartement de Chimie, Faculté des Sciences Semlalia, Cadi Ayyad University, BP, 2390, Marrakech, Morocco.
Julie A PollockDepartment of Chemistry, University of Richmond, Gottwald Center for the Sciences, Richmond, VA, 23173, USA.
Carol A ParishDepartment of Chemistry, University of Richmond, Gottwald Center for the Sciences, Richmond, VA, 23173, USA.
Cadi Ayyad University · MAUniversity of Richmond · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is a global pandemic caused by infection with the SARS-CoV-2 virus. Remdesivir, a SARS-CoV-2 RNA polymerase inhibitor, is the only drug to have received widespread approval for treatment of COVID-19. The SARS-CoV-2 main protease enzyme (M

Indexed as

Binding assayCoronavirusCOVID-19Drug discoveryIndazoleInhibitorsMolecular dynamicsMProProteaseSARS-CoV-2ScaffoldSubstrateThiazolylThiazolyl-indazole

Identifiers

PMID37519829
PMCPMC8828376
OpenAlexW4220776256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.