Evidence map›Paper›PMID 37519458›Full record

ArticleBiological psychiatry global open science2023

Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene.

Manuel F López-Aranda, Gayle M Boxx, Miranda Phan, Karen Bach, Rochelle Mandanas, Isaiah Herrera, Sunrae Taloma, Chirag Thadani, Odilia Lu, Raymond Bui and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Manuel F López-ArandaDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Gayle M BoxxDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California.
Miranda PhanDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Karen BachDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Rochelle MandanasDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Isaiah HerreraDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Sunrae TalomaDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Chirag ThadaniDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Odilia LuDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Raymond BuiDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
Shuhan LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, China.
Nan LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, China.
Yu ZhouDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, China.
Genhong ChengDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California.
Alcino J SilvaDepartments of Neurobiology, Psychology, and Psychiatry, University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · USQingdao University · CN

Funding

Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
NINDS NIH HHS T32 NS115706
6 · The paper itself

Abstract

Background: Tuberous sclerosis complex is a genetic disorder associated with high rates of intellectual disability and autism. Mice with a heterozygous null mutation of the Methods: To test the possible role of microglia and type I interferon in abnormal hippocampal-dependent memory and LTP of Results: Unexpectedly, we demonstrate that male, but not female, Conclusions: Microglia and IFNAR1 signaling have a key role in the hippocampal-dependent memory deficits and abnormal hippocampal LTP of

Indexed as

Hippocampal memoryLTPMicrogliaOPRTsc2Type I IFN

Identifiers

PMID37519458
PMCPMC10382699
OpenAlexW4226215988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.