ArticlePreventive medicine reports2023
The effects of sociodemographic factors and comorbidities on sepsis: A nationwide Swedish cohort study.
Article in Preventive medicine reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Association Between Community-Level Social Determinants of Health and Sepsis Incidence and Mortality: A Scoping Review.Critical care explorations · 2026Article
- Risk factors for sepsis mortality: A national Swedish cohort study (1998-2018).Clinics (Sao Paulo, Brazil) · 2026Article
- Socioeconomic disparities and mortality among acute patients with sepsis: a retrospective Danish cohort study.BMJ open · 2026Article
- Age-Comorbidity Interactions and Clinical Outcomes in Septic Shock: An Emergency Department-Based Multicenter Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Comparison of four noninvasive tools for predicting sepsis and septic shock mortality: a prospective cohort study.Clinical and experimental emergency medicine · 2026Article
- The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study.PLoS medicine · 2026Article
- Explainable machine learning models for mortality prediction in patients with sepsis in tertiary care hospital ICU in low- to middle-income countries.Intensive care medicine experimental · 2025Article
- Be-SNAP: the Belgian Sepsis National Action Plan.Frontiers in public health · 2025Article
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a severe condition, representing a significant public health concern, especially in the elderly. There is, however, little insight into the potential effects of sociodemographic factors and comorbidities on sepsis incidence and how these factors interact. This was a nationwide open cohort study including individuals (N = 6 746 010) in Sweden ≥ 18 years of age spanning from 1997 to 2018, with 116 175 995 person years of follow-up. The outcome was time to first occurrence of sepsis. The following variables were included in the analysis: sociodemographic factors (age, sex, income, education, marital status, region of residency, and country of origin), severe mental disorders (schizophrenia and bipolar disorders), and Charlson Comorbidity Index. Interaction tests were conducted. A total of 161 558 individuals were diagnosed with sepsis during the study period, corresponding to an incidence rate of 13.9 per 10 000 person years (95% CI: 13.8 - 14.0). The main findings were that male sex, high age, low education, and comorbid conditions were positively associated with sepsis, after adjustments for the other covariates. Being aged 80 years and above yielded a HR of 18.19 (95% CI: 17.84 - 18.55) and the effect of high age was more than twice as high in men than in women. In conclusion, this large nationwide cohort found that several sociodemographic factors and comorbid conditions were independently associated with sepsis and men were more affected by higher age than women. These findings can help improve sepsis awareness and preventive work in risk groups.
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