Evidence map›Paper›PMID 37519269›Full record

ArticleDevelopment (Cambridge, England)2023

Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes.

Magdalena Schindler, Marco Osterwalder, Izabela Harabula, Lars Wittler, Athanasia C Tzika, Dina K N Dechmann, Martin Vingron, Axel Visel, Stefan A Haas, Francisca M Real

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Function and Evolution of the Loop Extrusion Machinery in Animals.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Magdalena SchindlerGene Regulation & Evolution, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.ORCID 0000-0003-3363-1864
Marco OsterwalderDepartment for BioMedical Research (DBMR), University of Bern, Bern 3008, Switzerland.
Izabela HarabulaEpigenetic Regulation and Chromatin Architecture, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin 10115, Germany.
Lars WittlerDepartment of Developmental Genetics, Transgenic Unit, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Athanasia C TzikaDepartment of Genetics & Evolution, University of Geneva, Geneva 1205, Switzerland.
Dina K N DechmannDepartment of Migration, Max Planck Institute for Animal Behavior, Radolfzell 78315, Germany.
Martin VingronDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Stefan A HaasDepartment of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Francisca M RealGene Regulation & Evolution, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.ORCID 0000-0003-0692-2260
Max Planck Institute for Molecular Genetics · DELawrence Berkeley National Laboratory · USMax Delbrück Center · DEUniversity of Bern · CHUniversity of Geneva · CHUniversity of Konstanz · DE

Funding

Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1M
In Vivo Characterization of Major ENCODE-Predicted Classes of Noncoding ElementsUM1HG009421 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2017 to 2021
$6.8M
A Single-Cell Resolution Enhancer Atlas of Craniofacial DevelopmentR01DE028599 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VISEL, AXEL · 2019 to 2023
$4.2M
In vivo Characterization of Regulatory Variant Pathogenicity in Congenital Heart DiseaseR01HL162304 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2022 to 2025
$3.0M
NHGRI NIH HHS R01 HG003988NHGRI NIH HHS UM1 HG009421NHLBI NIH HHS R01 HL162304NIDCR NIH HHS R01 DE028599
6 · The paper itself

Abstract

Changes in gene expression represent an important source of phenotypic innovation. Yet how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing integrative analyses of epigenetic and transcriptional data in mole and mouse, we identified the co-option of SALL1 expression in mole ovotestes formation. Chromosome conformation capture analyses highlight a striking conservation of the 3D organization at the SALL1 locus, but an evolutionary divergence of enhancer activity. Interspecies reporter assays support the capability of mole-specific enhancers to activate transcription in urogenital tissues. Through overexpression experiments in transgenic mice, we further demonstrate the capability of SALL1 to induce kidney-related gene programs, which are a signature of mole ovotestes. Our results highlight the co-option of gene expression, through changes in enhancer activity, as a plausible mechanism for the evolution of traits.

Indexed as

KidneyMolesAnimalsFemaleMiceMice, TransgenicEvolutionary genomicsGene regulationGonad developmentMolesOvotestesSALL1

Identifiers

PMID37519269
PMCPMC10499028
OpenAlexW4385406855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.