Evidence map›Paper›PMID 37519213›Full record

ArticleBritish journal of haematology2023

Case report: Rare case of donor cell-derived T-cell acute lymphoblastic leukaemia in a female patient after receiving an allo-transplant from her male sibling.

Laura N Eadie, Jacqueline A Rehn, Caitlin E Schutz, Susan L Heatley, Monika M Kutyna, Devendra K Hiwase, Deborah L White, David T Yeung

Open access · hybridAbstract readCase Reports
In one paragraph

Article in British journal of haematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Laura N EadiePrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0003-1912-7602
Jacqueline A RehnPrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0001-5043-6943
Caitlin E SchutzPrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Susan L HeatleyPrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0001-7497-6477
Monika M KutynaPrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Devendra K HiwasePrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Deborah L WhitePrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0003-4844-333X
David T YeungPrecision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0002-7558-9927
South Australian Health and Medical Research Institute · AURoyal Adelaide Hospital · AU

Funding

Bristol-Myers SquibbCancer Council South Australia 022213Medical Research Future Fund (MRFF) 2020/MRF1195517National Health and Medical Research Council 1146253National Health and Medical Research Council 1160833Peter Nelson Leukaemia Research Fellowship Fund 022212The Kids' Cancer Project 022214
6 · The paper itself

Abstract

Donor-derived haematological neoplasms, in which recipients present with haematological malignancies that have evolved from transplant donor stem cells, have previously been described for myelodysplastic syndrome, myeloproliferative neoplasms, acute myeloid leukaemia and less often, leukaemias of lymphoid origin. Here we describe a rare and complex case of donor-derived T-cell acute lymphoblastic leukaemia with a relatively short disease latency of less than 4 years. Through genomic and in vitro analyses, we identified novel mutations in NOTCH1 as well as a novel activating mutation in STAT5B; the latter targetable with the clinically available drugs, venetoclax and ruxolitinib.

Indexed as

Leukemia, Myeloid, AcutePrecursor T-Cell Lymphoblastic Leukemia-LymphomaFemaleHumansMaleSiblingsTissue DonorsT-Lymphocytesacute lymphoblastic leukaemiacase reportchromosomal abnormalitiesCNOT3DNMT3Adonor-derived haematological neoplasmsKMT2DmRNA-sequencingNOTCH1precision medicineSTAT5B

Identifiers

PMID37519213
PMCPMC10953359
OpenAlexW4385405909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.