Evidence map›Paper›PMID 37519211›Full record

ReviewIntestinal research2023

Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease.

You Sun Kim, Edward H Hurley, Yoojeong Park, Sungjin Ko

Open access · diamondAbstract readReview
In one paragraph

Review in Intestinal research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

You Sun KimDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Edward H HurleyDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yoojeong ParkDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sungjin KoDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · USHallym University · KR

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER · 2019 to 2026
$10.9M
Identifying therapeutic options for intrahepatic cholangiocarcinomaR01CA258449 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KO, SUNGJIN · 2021 to 2025
$1.6M
NCI NIH HHS R01 CA258449NIDDK NIH HHS P30 DK120531NIH HHS 1R01CA258449
6 · The paper itself

Abstract

Primary sclerosing cholangitis (PSC) is a progressive cholestatic, inflammatory, and fibrotic disease that is strongly associated with inflammatory bowel disease (IBD). PSC-IBD represents a unique disease entity and patients with this disease have an increased risk of malignancy development, such as colorectal cancer and cholangiocarcinoma. The pathogenesis of PSC-IBD involves genetic and environmental factors such as gut dysbiosis and bile acids alteration. However, despite the advancement of disease characteristics, no effective medical therapy has proven to have a significant impact on the prognosis of PSC. The treatment options for patients with PSC-IBD do not differ from those for patients with PSC alone. Potential candidate drugs have been developed based on the pathogenesis of PSC-IBD, such as those that target modulation of bile acids, inflammation, fibrosis, and gut dysbiosis. In this review, we summarize the current medical treatments for PSC-IBD and the status of new emerging therapeutic agents.

Indexed as

Inflammatory bowel diseasePrimary sclerosing cholangitisTherapeutics

Identifiers

PMID37519211
PMCPMC10626010
OpenAlexW4385406975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.