ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2023
Chemical elucidation of acute encephalopathy by ingestion of angel-wing mushroom (Pleurocybella porrigens) - involvement of three constituents in onset.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- The complete mitochondrial genome sequence of the angel-wing mushroomMitochondrial DNA. Part B, Resources · 2026Article
- A high-quality genome assembly of angel-wing mushroom Pleurocybella porrigens that causes acute encephalopathy.AMB Express · 2025Article
- RNA-Seq analysis of the fruiting bodies and mycelia of angel-wing mushroom Pleurocybella porrigens that cause acute encephalopathy.BMC research notes · 2024Article
- Mushroom poisoning: An updated review.Turkish journal of emergency medicineReview
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
The mushroom, Pleurocybella porrigens, is widely consumed in Japan; however, in autumn 2004, acute encephalopathy due to ingestion of the mushroom in a large group of patients was reported in Japan. We have continued working on the mushroom to clarify the mechanisms underlying the acute encephalopathy that occurred due to its consumption. The data collected to date have shown that three compounds, pleurocybelline (PC), a Pleurocybella porrigens lectin (PPL), and pleurocybellaziridine (PA), in the mushroom are potentially responsible for the onset of the disease; PC that exhibit lethal activity in mice and PPL formed a complex, and the complex of the two components exhibited proteolytic activity and disrupted the blood-brain barrier. Although PA was not isolated directly from the mushroom, the existence of this compound in the mushroom was predicted. The compound was chemically synthesized and its endogeneity in the mushroom was demonstrated. Furthermore, PA exhibited toxicity to oligodendrocytes.
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