Evidence map›Paper›PMID 37517995›Full record

ArticleJournal of biomedical science2023

Intranasal administration of Lactobacillus johnsonii attenuates hyperoxia-induced lung injury by modulating gut microbiota in neonatal mice.

Chung-Ming Chen, Yu-Chen S H Yang, Hsiu-Chu Chou, Shan Lin

Open access · diamondAbstract read
In one paragraph

Article in Journal of biomedical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. The gut-lung axis in early life: microbiome-associated mechanisms and clinical relevance.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Article
  4. Toward development of soil-derivedBiodesign research · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Strain-resolved biology ofFrontiers in veterinary science · 2026
    Review
  11. Microbiome TherapeuticJournal of microbiology and biotechnology · 2025
    Article
  12. iMetaOmics · 2025
    Article
  13. [Toxicity of lunar dust simulant exposure via the digestive system: Microbiota dysbiosis and multi-organ injury].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  14. Article
  15. Hyperoxia as a driver of gut dysbiosis.Frontiers in microbiology · 2025
    Review
  16. Unveiling the potential ofFrontiers in microbiology · 2025
    Review
  17. Review
  18. Impact of hyperoxia on the gut during critical illnesses.Critical care (London, England) · 2024
    Review
  19. Observational
  20. Safety Evaluation of an Intranasally Applied Cocktail ofAnimals : an open access journal from MDPI · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Chung-Ming ChenDepartment of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan. cmchen@tmu.edu.tw.ORCID http://orcid.org/0000-0001-8762-8957
Yu-Chen S H YangJoint Biobank, Office of Human Research, Taipei Medical University, Taipei, Taiwan.
Hsiu-Chu ChouDepartment of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Shan LinBiotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan.
Taipei Medical University · TWGrape King (Taiwan) · TWTaipei Medical University Hospital · TW

Funding

Ministry of Science and Technology in Taiwan MOST 110-2622-B-038-006
6 · The paper itself

Abstract

backgroundSupplemental oxygen impairs lung development in newborn infants with respiratory distress. Lactobacillus johnsonii supplementation attenuates respiratory viral infection in mice and exhibits anti-inflammatory effects. This study investigated the protective effects of intranasal administration of L. johnsonii on lung development in hyperoxia-exposed neonatal mice.

methodsNeonatal C57BL/6N mice were reared in either room air (RA) or hyperoxia condition (85% O

resultsThe O

conclusionsIntranasal administration of L. johnsonii protects against hyperoxia-induced lung injury and modulates the gut microbiota.

Indexed as

Gastrointestinal MicrobiomeHyperoxiaLactobacillus johnsoniiLung InjuryAdministration, IntranasalAnimalsAnimals, NewbornCytokinesLungMiceMice, Inbred C57BLRatsRats, Sprague-DawleyCytokinesHyperoxiaMean linear interceptMicrobiotaProbioticsVascular endothelial growth factor

Identifiers

PMID37517995
PMCPMC10388480
OpenAlexW4385397322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.