Evidence map›Paper›PMID 37517631›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2024

The Association Between a Mediterranean Diet and Symptoms of Irritable Bowel Syndrome.

Ellie Y Chen, Swapna Mahurkar-Joshi, Cathy Liu, Nancee Jaffe, Jennifer S Labus, Tien S Dong, Arpana Gupta, Shravya Patel, Emeran A Mayer, Lin Chang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ellie Y ChenVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California.
Swapna Mahurkar-JoshiVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; UCLA Goodman-Luskin Microbiome Center, Los Angeles, California.
Cathy LiuVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; UCLA Goodman-Luskin Microbiome Center, Los Angeles, California.
Nancee JaffeVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California.
Jennifer S LabusVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; UCLA Goodman-Luskin Microbiome Center, Los Angeles, California.
Tien S DongVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; UCLA Goodman-Luskin Microbiome Center, Los Angeles, California.
Arpana GuptaVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; UCLA Goodman-Luskin Microbiome Center, Los Angeles, California.
Shravya PatelUniversity of California, Los Angeles, Los Angeles, California.
Emeran A MayerVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; UCLA Goodman-Luskin Microbiome Center, Los Angeles, California.
Lin ChangVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, California; UCLA Goodman-Luskin Microbiome Center, Los Angeles, California. Electronic address: linchang@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
PROFILING VULVODYNIA BASED ON NEUROBIOLOGICAL AND BEHAVIORAL ENDOPHENOTYPESR01HD076756 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LABUS, JENNIFER S, RAPKIN, ANDREA J · 2013 to 2017
$1.8M
Role of Inflammatory Processes in Reward Network Alterations in ObesityK23DK106528 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2016 to 2020
$1.0M
Role of the Gut Microbiome in Reward Network Alterations in ObesityR03DK121025 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2020 to 2021
$234k
NCATS NIH HHS UL1 TR001881NICHD NIH HHS R01 HD076756NIDDK NIH HHS K23 DK106528NIDDK NIH HHS R01 DK048351NIDDK NIH HHS R03 DK121025
6 · The paper itself

Abstract

BACKGROUND &

aimsLow adherence to Mediterranean diet (MD) has been shown to be associated with a higher prevalence of irritable bowel syndrome (IBS), but its association with IBS symptoms is not established. We aim to assess the association between MD and IBS symptoms, identify components of MD associated with IBS symptoms, and determine if a symptom-modified MD is associated with changes in the gut microbiome.

methodsOne hundred and six Rome +IBS and 108 health control participants completed diet history and gastrointestinal symptom questionnaires. Adherence to MD was measured using Alternate Mediterranean Diet and Mediterranean Diet Adherence Screener. Sparse partial least squares analysis identified MD food items associated with IBS symptoms. Stool samples were collected for 16S ribosomal RNA gene sequencing and microbial composition analysis in IBS subjects.

resultsAlternate Mediterranean Diet and Mediterranean Diet Adherence Screener scores were similar between IBS and health control subjects and did not correlate with Irritable Bowel Syndrome Severity Scoring System, abdominal pain, or bloating. Among IBS participants, a higher consumption of fruits, vegetables, sugar, and butter was associated with a greater severity of IBS symptoms. Multivariate analysis identified several MD foods to be associated with increased IBS symptoms. A higher adherence to symptom-modified MD was associated with a lower abundance of potentially harmful Faecalitalea, Streptococcus, and Intestinibacter, and higher abundance of potentially beneficial Holdemanella from the Firmicutes phylum.

conclusionsA standard MD was not associated with IBS symptom severity, although certain MD foods were associated with increased IBS symptoms. Our study suggests that standard MD may not be suitable for all patients with IBS and likely needs to be personalized in those with increased symptoms.

Indexed as

Diet, MediterraneanGastrointestinal DiseasesGastrointestinal MicrobiomeIrritable Bowel SyndromeDietFoodHumansIrritable Bowel SyndromeMediterranean DietMicrobiomeSymptoms

Identifiers

PMID37517631
PMCPMC10849937
OpenAlexW4385337327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.