Evidence map›Paper›PMID 37517321›Full record

ArticleDNA repair2023

Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 in sub-Saharan African populations.

Jamie T Zuckerman, Irina G Minko, Melis Kant, Pawel Jaruga, Michael P Stone, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Aflatoxin BEnvironmental and molecular mutagenesis · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Research progress on the role of the NEIL family in cancer.Frontiers in cell and developmental biology · 2025
    Review
  6. Article
  7. Frequencies and spectra of aflatoxin BNAR molecular medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jamie T ZuckermanOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States.
Irina G MinkoOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States.
Melis KantBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Pawel JarugaBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Michael P StoneDepartment of Chemistry, Vanderbilt University, Nashville, TN 37240, United States.
Miral DizdarogluBiomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Amanda K McCulloughOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, United States.
R Stephen LloydOregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, United States; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, United States. Electronic address: lloydst@ohsu.edu.
Oregon Health & Science University · USMaterial Measurement Laboratory · USNational Institute of Standards and Technology · USVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
DNA Adduct-Induced MutagenesisR01CA055678 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 1992 to 2016
$4.0M
DNA Adduct-Induced MutagenesisR01ES029357 · NIEHS · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2018 to 2022
$2.6M
Role of Base Excision Repair in Limiting Hepatocellular Carcinomas -Administrative SupplementR01ES031086 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LLOYD, R. STEPHEN · 2020 to 2024
$2.0M
NCI NIH HHS P01 CA160032NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA055678NIEHS NIH HHS R01 ES029357NIEHS NIH HHS R01 ES031086
6 · The paper itself

Abstract

Nei-like glycosylase 1 (NEIL1) is a DNA repair enzyme that initiates the base excision repair (BER) pathway to cleanse the human genome of damage. The substrate specificity of NEIL1 includes several common base modifications formed under oxidative stress conditions, as well as the imidazole ring open adducts that are induced by alkylating agents following initial modification at N7 guanine. An example of the latter is the persistent and mutagenic 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B

Indexed as

Carcinoma, HepatocellularDNA GlycosylasesLiver NeoplasmsDNA RepairHumansMutagenesisNucleotidesDNA GlycosylasesNEIL1 protein, humanNucleotidesAflatoxinBase excision repairChronic inflammationDNA damageHepatocellular carcinoma

Identifiers

PMID37517321
PMCPMC10546947
OpenAlexW4384937668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.