Evidence map›Paper›PMID 37517263›Full record

ArticleDrug and alcohol dependence2023

Associations of polygenic risk scores for smoking heaviness and lifetime cannabis use with tobacco and cannabis co-use trajectories among African Americans.

Jill A Rabinowitz, Beth A Reboussin, David W Sosnowski, Sally I-Chun Kuo, Justin C Strickland, Luis M García-Marín, Miguel E Rentería, Nathan Gillespie, Brion Maher, Nicholas S Ialongo and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Jill A RabinowitzDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: jrabino3@jhmi.edu.
Beth A ReboussinDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
David W SosnowskiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sally I-Chun KuoDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
Justin C StricklandDepartment of Psychiatry and Behavioral Services, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Luis M García-MarínMental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland4006, Australia; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland4012, Australia.
Miguel E RenteríaMental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland4006, Australia; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland4012, Australia.
Nathan GillespieDepartment of Psychiatry, Virginia Commonwealth University School of Medicine, USA.
Brion MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Nicholas S IalongoDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Roland J ThorpeDepartment of Psychiatry and Behavioral Services, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
George UhlNew Mexico VA Health Care SystemAlbuquerque, NMUSA.
Johns Hopkins University · USThe University of Queensland · AUNew Mexico VA Health Care System · USRutgers, The State University of New Jersey · USVirginia Commonwealth University · USWake Forest University · US

Funding

PERIODIC FOLLOW UP OF TWO UNIVERSAL PREVENTIVE TRIALSR01MH057005 · NIMH · JOHNS HOPKINS UNIVERSITY · PI IALONGO, NICHOLAS S · 1998 to 2007
$4.2M
Development & Malleability from Childhood to AdulthoodR01DA044184 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IALONGO, NICHOLAS S · 2018 to 2022
$3.9M
FOLLOWUP OF TWO UNIVERSAL PREVENTIVE INTERVENTIONSR01DA011796 · NIDA · JOHNS HOPKINS UNIVERSITY · PI IALONGO, NICHOLAS S · 1999 to 2004
$2.0M
Genes, Environment and Drug Use in Three Baltimore CohortsR01DA036525 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MAHER, BRION S · 2015 to 2017
$727k
NIDA NIH HHS R01 DA011796NIDA NIH HHS R01 DA036525NIDA NIH HHS R01 DA044184NIMHD NIH HHS L60 MD017785NIMH NIH HHS R01 MH057005
6 · The paper itself

Abstract

backgroundWe aimed to identify distinct trajectories of tobacco, cannabis, and their co-use among African Americans, and to investigate whether these patterns were associated with polygenic risk scores (PRS) for tobacco and cannabis use.

methodParticipants (N=428 participants; 50.9% male) were initially recruited for an elementary school-based prevention in a Mid-Atlantic city when they were in first grade. From ages 14-26, participants reported on their frequency of tobacco and cannabis use in the past year during annual assessments. DNA was collected from participants at age 21. PRS for smoking heaviness (i.e., cigarettes per day) and lifetime cannabis use were created based on genome-wide association study results derived from Liu et al. (2019) and Pasman et al. (2018), respectively.

resultsWe identified five distinct trajectories of tobacco and cannabis co-use, including (1) Low Tobacco and Cannabis Use, (2) Adolescent Limited Tobacco and Cannabis Use, (3) Experimental Cannabis, Young Adult Increasing Tobacco, (4) Experimental Tobacco, Young Adult Increasing Cannabis, and (5) High, Chronic Tobacco and Cannabis Use. Compared to the Low Tobacco and Cannabis Use subgroup, individuals in the High, Chronic Tobacco and Cannabis Use subgroup had greater PRS for smoking heaviness, and individuals in the Experimental Cannabis, Young Adult Increasing Tobacco subgroup had higher PRS for lifetime cannabis use.

conclusionsPolygenic risk for lifetime cannabis use and smoking heaviness is associated with the developmental progression of tobacco and cannabis co-use among African Americans, furthering knowledge on the etiology of co-use in this population.

Indexed as

Cigarette SmokingMarijuana UseAdolescentAdultBlack or African AmericanCannabisFemaleGenome-Wide Association StudyHumansMaleMultifactorial InheritanceRisk FactorsSmokingYoung AdultAfrican AmericanCannabis useCo-usePolygenic risk scoresTobacco use

Identifiers

PMID37517263
PMCPMC10495192
OpenAlexW4383956821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.