Evidence map›Paper›PMID 37517088›Full record

ArticleAging2023

LncRNA NORAD defects deteriorate the formation of age-related macular degeneration.

Jinfeng Zhang, Jing Jiang, Hongyu Zhou, Shenjun Li, Weihua Bian, Lifu Hu, Daolai Zhang, Cong Xu, Yeying Sun

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. ASNS Regulates HBioFactors (Oxford, England)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jinfeng ZhangCollege of Pharmacy, Binzhou Medical University, Shandong, China.
Jing JiangCollege of Pharmacy, Binzhou Medical University, Shandong, China.
Hongyu ZhouCollege of Pharmacy, Binzhou Medical University, Shandong, China.
Shenjun LiNon-Clinical Research Department, RemeGen Co., Ltd, Shandong, China.
Weihua BianCollege of Pharmacy, Binzhou Medical University, Shandong, China.
Lifu HuNon-Clinical Research Department, RemeGen Co., Ltd, Shandong, China.
Daolai ZhangCollege of Pharmacy, Binzhou Medical University, Shandong, China.
Cong XuCollege of Pharmacy, Binzhou Medical University, Shandong, China.
Yeying SunCollege of Pharmacy, Binzhou Medical University, Shandong, China.
Binzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) play important roles in the development of age-related macular degeneration (AMD). However, the effect of long non-coding RNA activated by DNA damage (NORAD) on AMD remains unknown. This study aimed to investigate the effect of NORAD on RPE cell senescence and degeneration. Irradiated adult retinal pigment epithelial cell line-19 (ARPE-19) and sodium iodate-treated mice were used as

Indexed as

Macular DegenerationRNA, Long NoncodingAnimalsIodatesMiceOxidative StressReactive Oxygen SpeciesRetinal Pigment EpitheliumRetinal PigmentsSirtuin 1Tumor Suppressor Protein p53IodatesReactive Oxygen SpeciesRetinal PigmentsRNA, Long NoncodingSirtuin 1sodium iodateTumor Suppressor Protein p53age-related macular degenerationLncRNA NORADPGC-1αsenescenceSIRT1

Identifiers

PMID37517088
PMCPMC10457045
OpenAlexW4385376809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.