ArticleAge and ageing2023
Exploring the natural history of intrinsic capacity impairments: longitudinal patterns in the 10/66 study.
Article in Age and ageing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Transitions and trajectories in intrinsic capacity states over time: a systematic review.BMC geriatrics · 2025Pooled it
- The assessment and detection rate of intrinsic capacity deficits among older adults: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Intrinsic capacity and mortality in community-dwelling octogenarians: a network analysis from the ilSIRENTE study.GeroScience · 2026Article
- Association of Composite and Domain-Specific Intrinsic Capacity and Frailty Among Older Adults in India: Evidence from the Longitudinal Ageing Study in India (LASI).Journal of frailty, sarcopenia and falls · 2026Article
- Mapping the impact of intrinsic capacity on healthcare use.The journal of nutrition, health & aging · 2026Article
- Digital Divide or Compensatory Dividend? The Longitudinal Impact of Smart Health Monitoring on Intrinsic Capacity Trajectories.Healthcare (Basel, Switzerland) · 2026Article
- Intrinsic capacity across the adult lifespan in China: baseline analysis from the nationwide longitudinal PENG ZU cohort.GeroScience · 2026Article
- The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo Study for Healthy Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Hearing loss associated with mobility and cognitive impairment: comorbid condition, an intrinsic capacity-aligned vulnerability cluster or a syndromic clustering?The journal of nutrition, health & aging · 2026Article
- Association between aspirin use and decline in intrinsic capacity among community-dwelling elderly: a study based on the Lianyungang ICOPE pilot project.Frontiers in medicine · 2026Article
- Determinants of intrinsic capacity among older adults in low- and middle-income countries: A scoping review.Belitung nursing journal · 2025Review
- Assessing intrinsic capacity for person-centred HIV care: a cross-sectional study in ageing populations in Malaysia and Hong Kong.Journal of the International AIDS Society · 2025Article
- Intrinsic capacity transitions predict overall and cause-specific mortality, incident disability, and healthcare utilization.The journal of nutrition, health & aging · 2024Article
- Real-life intrinsic capacity screening data from the ICOPE-Care program.Nature aging · 2024Article
- Transitions in intrinsic capacity among community-dwelling older people and their associated factors: a multistate modelling analysis.The journal of nutrition, health & aging · 2024Article
- Factors associated with intrinsic capacity impairment in hospitalized older adults: a latent class analysis.BMC geriatrics · 2024Article
- Intrinsic capacity construct and influencing factors.The journal of nutrition, health & aging · 2024Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 6 countries.
Funding
Abstract
backgroundintrinsic capacity (IC) is a construct encompassing people's physical and mental abilities. There is an implicit link amongst IC domains: cognition, locomotion, nutrition, sensory and psychological. However, little is known about the integration of the domains.
objectivesto investigate patterns in the presentation and evolution of IC domain impairments in low-and-middle-income countries and if such patterns were associated with adverse outcomes.
methodssecondary analyses of the first two waves of the 10/66 study (population-based surveys conducted in eight urban and four rural catchment areas in Cuba, Dominican Republic, Puerto Rico, Venezuela, Peru, Mexico and China). We applied latent transition analysis on IC to find latent statuses (latent clusters) of IC domain impairments. We evaluated the longitudinal association of the latent statuses with the risk of frailty, disability and mortality, and tested concurrent and predictive validity.
resultsamongst 14,923 participants included, the four latent statuses were: high IC (43%), low deterioration with impaired locomotion (17%), high deterioration without cognitive impairment (22%), and high deterioration with cognitive impairment (18%). A total of 61% of the participants worsened over time, 35% were stable, and 3% improved to a healthier status.Participants with deteriorated IC had a significantly higher risk of frailty, disability and dementia than people with high IC. There was strong concurrent and predictive validity. (Mortality Hazard Ratio = 4.60, 95%CI 4.16; 5.09; Harrel's C = 0.73 (95%CI 0.72;0.74)).
conclusionshalf of the study population had high IC at baseline, and most participants followed a worsening trend. Four qualitatively different IC statuses or statuses were characterised by low and high levels of deterioration associated with their risk of disability and frailty. Locomotion and cognition impairments showed other trends than psychological and nutrition domains across the latent statuses.
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