Evidence map›Paper›PMID 37517038›Full record

SynthesisJournal of neurology2023

Role of expectations in clinical outcomes after deep brain stimulation in patients with Parkinson's disease: a systematic review.

Francesca Mameli, Eleonora Zirone, Roberta Girlando, Elena Scagliotti, Giulia Rigamonti, Edoardo Nicolò Aiello, Barbara Poletti, Roberta Ferrucci, Nicola Ticozzi, Vincenzo Silani and 3 more

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham-Controlled Trial.Movement disorders : official journal of the Movement Disorder Society · 2026
    Trial
  2. Psychiatric consultation outcomes in deep brain stimulation candidacy: clinical and psychosocial correlates from a retrospective cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Francesca Mameli *Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy. francesca.mameli@policlinico.mi.it.ORCID http://orcid.org/0000-0003-4774-582X
Eleonora Zirone *Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.ORCID http://orcid.org/0000-0002-0935-8645
Roberta GirlandoFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.ORCID http://orcid.org/0009-0008-0652-9139
Elena ScagliottiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.ORCID http://orcid.org/0009-0004-9102-7547
Giulia RigamontiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.ORCID http://orcid.org/0009-0000-3305-1515
Edoardo Nicolò AielloDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID http://orcid.org/0000-0001-8902-7733
Barbara PolettiDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID http://orcid.org/0000-0003-4398-2051
Roberta FerrucciASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, Italy.ORCID http://orcid.org/0000-0001-5109-9483
Nicola TicozziDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID http://orcid.org/0000-0001-5963-7426
Vincenzo SilaniDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.ORCID http://orcid.org/0000-0002-7698-3854
Marco LocatelliFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.ORCID http://orcid.org/0000-0003-0778-3653
Sergio BarbieriFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.ORCID http://orcid.org/0000-0001-9414-6307
Fabiana RuggieroFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.ORCID http://orcid.org/0000-0003-0471-4476
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Milan · ITIRCCS Istituto Auxologico Italiano · IT

Funding

Ministero della Salute IRCCS RC-2023 Grant no. 01Ministero della Salute project 23C923Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

Deep brain stimulation (DBS) is a well-established treatment that significantly improves the motor symptoms of patients with Parkinson's disease (PD); however, patients may experience post-operative psychological distress and social maladjustments. This phenomenon has been shown to be related to patients' pre-operative cognitive representations, such as expectations. In this systematic review, we discuss the findings on the role of the expectations of patients with PD regarding the clinical outcomes of DBS to identify areas of intervention to improve pre-operative patient education and promote successful post-operative psychosocial adjustment. PubMed was searched for relevant articles published up to 16 January 2023. Of the 84 identified records, 10 articles focusing on the treatment expectations of patients with PD undergoing DBS were included in this review. The selected studies were conducted among cohorts of patients with different DBS targets, among which the most common was the bilateral subthalamic nucleus. Overall, the data showed that patients' expectations contribute to treatment efficacy. Experiments investigating the placebo effect itself have shown clinical improvement after the induction of positive therapeutic expectations; conversely, unrealistic treatment expectations can affect patient satisfaction after surgery, clinical outcomes, and subjective well-being. This review highlights the need for routine clinical practice to better investigate and manage patients' pre-operative expectations, as well as multidisciplinary education to improve patient satisfaction and psychosocial adjustment after DBS.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusHumansMotivationTreatment OutcomeDeep brain stimulationParkinson diseasePatients’ expectationsPlaceboSubthalamic nucleus

Identifiers

PMID37517038
PMCPMC10576668
OpenAlexW4385389015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.