Evidence map›Paper›PMID 37516858›Full record

ArticleDiagnostic pathology2023

Pathogenesis diagnosis of a pediatric patient suffering from multi-organ abscesses.

Mingkun Wu, Haijuan Xiao, Yan Xiao, Tianming Chen, Xinming Wang, Xia Xiao, Ying Wang, Jianwei Wang, Lili Ren, Gang Liu

Open access · goldAbstract read
In one paragraph

Article in Diagnostic pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mingkun Wu *National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China.
Haijuan Xiao *Department of Infectious Diseases, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Ministry of Education, Capital Medical University, National Center for Children's Health, No.56 NanLiShi Road, Xicheng District, 100045, Beijing, P. R. China.
Yan XiaoNational Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China.
Tianming ChenDepartment of Infectious Diseases, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Ministry of Education, Capital Medical University, National Center for Children's Health, No.56 NanLiShi Road, Xicheng District, 100045, Beijing, P. R. China.
Xinming WangNational Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China.
Xia XiaoNational Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China.
Ying WangNational Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China.
Jianwei WangNational Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China. wangjw28@163.com.
Lili RenNational Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China. renliliipb@163.com.
Gang LiuDepartment of Infectious Diseases, Key Laboratory of Major Diseases in Children, Beijing Children's Hospital, Ministry of Education, Capital Medical University, National Center for Children's Health, No.56 NanLiShi Road, Xicheng District, 100045, Beijing, P. R. China. liugang@bch.com.cn.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Children’s Hospital · CNPeking Union Medical College Hospital · CN

Funding

Beijing Municipal Natural Science Foundation of China Z190017Beijing Natural Science Foundation L202004Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-I2M-1-038Fundamental Research Funds for the Central Universities 3332021092Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences 2019PT310029Respiratory Research Project of National Clinical Research Center for Respiratory Diseases HXZX-202106The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority XTZD20180501
6 · The paper itself

Abstract

A pediatric patient suffered from renal and hepatic abscesses (through hepatorenal space) and recovered by antibiotics and other therapies. By clinical analysis, the multi-organ abscesses might be caused by bloodstream-disseminated infection. In order to identify the pathogen, we collected kidney biopsy tissue, swabs, and plasma samples, and used metagenomics next-generation sequencing (mNGS) and some traditional methods. The results revealed that polymicrobial especially anaerobic bacteremia (Bacteroides fragilis, et al.) contributed to the abscess formation. What is more, systematic human adenovirus C (HAdV-C) infection was shown, and the virus was isolated. The titer of HAdV-2 neutralizing antibodies was 1/4 in the plasma after symptoms onset. Although the exact mechanism of HAdV-2 infection in multiple abscess formation has not been clarified, the case of multi-organ abscesses in the context of polymicrobial especially anaerobic bacteremia and HAdV infection in healthy children is infrequent.

Indexed as

AbscessBacteremiaAnti-Bacterial AgentsAntibodies, NeutralizingChildHigh-Throughput Nucleotide SequencingHumansAnti-Bacterial AgentsAntibodies, NeutralizingAnaerobic bacteremiaBacteroides fragilisHuman adenovirus 2 (HAdV-2)Metagenomics next-generation sequencing (mNGS)Multi-organ abscesses

Identifiers

PMID37516858
PMCPMC10386630
OpenAlexW4385380515

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.