Evidence map›Paper›PMID 37516826›Full record

ArticleBMC complementary medicine and therapies2023

Anti-cancer effect of nano-encapsulated boswellic acids, curcumin and naringenin against HepG-2 cell line.

Sally Elnawasany, Yusuf A Haggag, Shahinaz M Shalaby, Nema A Soliman, Amira A El Saadany, Marwa A A Ibrahim, Farid Badria

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Cytotoxic Activity ofInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sally ElnawasanyTropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Gharbia, 31111, Egypt. Sally.elnawasany@med.tanta.edu.eg.ORCID http://orcid.org/0000-0002-7146-4238
Yusuf A HaggagDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Tanta, Gharbia, Egypt.
Shahinaz M ShalabyDepartment of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
Nema A SolimanMedical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
Amira A El SaadanyDepartment of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
Marwa A A IbrahimHistology Department, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
Farid BadriaPharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Tanta University · EGMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundliver cancer is one of the most common cancers in the world. So far, there is no gold standard treatment for hepatocellular carcinoma. We conducted this in vitro study to assess the effect of three natural products: Boswellic acids, curcumin and naringin versus corresponding nanoparticles (NPs) on Hep G2 cells proliferation.

methodsBoswellic acid, curcumin, naringin-loaded NPs were prepared using nanoprecipitation method. Human liver (HepG2) cell line was cultured in Dulbecco's modified Eagle's medium (DMEM). The cell growth inhibition and cytotoxicity were evaluated by MTT assay.

resultsBoswellic acid, curcumin, naringin were able to inhibit HepG2 cells proliferation. IC50 at 24 h, 48 h showed significant lower values in NPs versus Free herbs. IC50 values of free Boswellic acids and NPs at 24 h were (24.60 ± 1.89 and 7.78 ± 0.54, P < 0.001), at 48 h were (22.45 ± 1.13 and 5.58 ± 0.27, P < 0.001) respectively. IC50 values of free curcumin and NPs at 24 h were (5.89 ± 0.8 and 3.46 ± 0.23, P < 0.05), at 48 h were (5.57 ± 0.94 and 2.51 ± 0.11, P < 0.05), respectively. For free and naringenin NPs, IC50 values at 24 h were (14.57 ± 1.78 and 7.25 ± 0.17, P < 0.01), at 48 h were (11.37 ± 1.45 and 5.21 ± 0.18, P < 0.01) respectively.

conclusionBoswellic acid, curcumin, naringin and their nanoprecipitation prepared nanoparticles suppressed Hep G2 cells proliferation.

Indexed as

Carcinoma, HepatocellularCurcuminCell LineFlavanonesHumansTriterpenesboswellic acidCurcuminFlavanonesnaringeninTriterpenesApoptosisBoswellic acidsCurcuminHepatocellular CarcinomaNanoprecipitationNaringin

Identifiers

PMID37516826
PMCPMC10386659
OpenAlexW4385381433

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.