ArticleJournal of exposure science & environmental epidemiology2023
Practical application guide for the discovery of novel PFAS in environmental samples using high resolution mass spectrometry.
Article in Journal of exposure science & environmental epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Understanding and Reporting PFAS Exposure: Wide-Scope Retrospective Suspect Screening of High-Resolution Mass Spectrometry Data from Exposomics Studies.Environmental science & technology · 2026Article
- QuEChERS-Based LC-MS/MS and HRMS Methods for PFAS Determination in Food: A Systematic Review.Foods (Basel, Switzerland) · 2026Review
- Unraveling Plastic-Related Chemical Exposures during Pregnancy and Their Associations with Pregnancy Outcomes Using Suspect Screening Analysis.Environment & health (Washington, D.C.) · 2026Article
- Article
- The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity.International journal of molecular sciences · 2026Review
- Leachability and Chemical Profiles of Per- and Polyfluoroalkyl Substances in Electronic Waste Components: Targeted and Non-Targeted Analysis.Molecules (Basel, Switzerland) · 2026Article
- Optimization and Testing of an SPE-LC/q-TOF Analytical Method for the Detection of PFAS Degradation Products in Water Treatment Processes.Environmental science & technology · 2025Article
- Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry.Environmental science & technology · 2025Article
- Managing PFAS in Sewage Sludge: Exposure Pathways, Impacts, and Treatment Innovations.Journal of xenobiotics · 2025Review
- Practical Guidance on Selecting Analytical Methods for PFAS in Semiconductor Manufacturing Wastewater.ACS measurement science au · 2025Review
- Novel PFAS in alligator blood discovered with non-targeted ion mobility spectrometry-mass spectrometry.The Science of the total environment · 2025Article
- The ENTAiLS Toolkit: an integrated workflow to perform non-targeted analysis of per- and polyfluoroalkyl substances.Analytical and bioanalytical chemistry · 2025Article
- Structural and Quantitative Analysis of Polyfluoroalkyl Substances (PFASs) and Para-Phenylenediamines (PPDs) by Direct Analysis in Real Time Ion Mobility Mass Spectrometry (DART-IM-MS).Molecules (Basel, Switzerland) · 2025Article
- Exposure to per- and polyfluoroalkyl substances (PFAS) in North Carolina homes: results from the indoor PFAS assessment (IPA) campaign.Environmental science. Processes & impacts · 2025Article
- Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry.bioRxiv : the preprint server for biology · 2025Article
- Challenges Associated With PFAS Detection Method in Africa.Environmental health insights · 2025Review
- The Critical Role of Commercial Analytical Reference Standards in the Control of Chemical Risks: The Case of PFAS and Ways Forward.Environmental health perspectives · 2025Article
- Considerations and challenges in support of science and communication of fish consumption advisories for per- and polyfluoroalkyl substances.Integrated environmental assessment and management · 2024Review
- Characterizing the Areal Extent of PFAS Contamination in Fish Species Downgradient of AFFF Source Zones.Environmental science & technology · 2024Article
- Per- and Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies.Environmental science & technology · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe intersection of the topics of high-resolution mass spectrometry (HRMS) and per- and polyfluoroalkyl substances (PFAS) bring together two disparate and complex subjects. Recently non-targeted analysis (NTA) for the discovery of novel PFAS in environmental and biological media has been shown to be valuable in multiple applications. Classical targeted analysis for PFAS using LC-MS/MS, though growing in compound coverage, is still unable to inform a holistic understanding of the PFAS burden in most samples. NTA fills at least a portion of this data gap.
objectivesEntrance into the study of novel PFAS discovery requires identification techniques such as HRMS (e.g., QTOF and Orbitrap) instrumentation. This requires practical knowledge of best approaches depending on the purpose of the analyses. The utility of HRMS applications for PFAS discovery is unquestioned and will likely play a significant role in many future environmental and human exposure studies. METHODS/
resultsPFAS have some characteristics that make them standout from most other chemicals present in samples. Through a series of tell-tale PFAS characteristics (e.g., characteristic mass defect range, homologous series and characteristic fragmentation patterns), and case studies different approaches and remaining challenges are demonstrated. IMPACT STATEMENT: The identification of novel PFAS via non-targeted analysis using high resolution mass spectrometry is an important and difficult endeavor. This synopsis document will hopefully make current and future efforts on this topic easier to perform for novice and experienced alike. The typical time devoted to NTA PFAS investigations (weeks to months or more) may benefit from these practical steps employed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.