Evidence map›Paper›PMID 37516687›Full record

ArticleMolecular genetics and genomics : MGG2023

Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype-phenotype correlations in southern Chinese population.

Zhenggen Wu, Chukai Huang, Yuqian Zheng, Xiang-Ling Yuan, Shaowan Chen, Yanxuan Xu, Li Jia Chen, Chi Pui Pang, Mingzhi Zhang, Tsz Kin Ng

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Polymorphic variants ofInternational journal of ophthalmology · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Zhenggen Wu *Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Chukai Huang *Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Yuqian ZhengJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Xiang-Ling YuanJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Shaowan ChenJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Yanxuan XuJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China.
Li Jia ChenDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Chi Pui PangJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China. cppang@cuhk.edu.hk.
Mingzhi ZhangJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China. zmz@jsiec.org.
Tsz Kin NgJoint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Guangdong, Shantou, China. micntk@hotmail.com.ORCID http://orcid.org/0000-0001-7863-7229
Chinese University of Hong Kong · HK

Funding

General Research Fund from the Research Grants Council 14105916Internal grant from the Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong 19-001Internal grant from the Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong 20-020National Natural Science Foundation of China 82171044Special Fund for Science and Technology of Guangdong Province 2019ST016Special Fund for Science and Technology of Guangdong Province 2019ST017Special Fund for Science and Technology of Guangdong Province 2019ST024
6 · The paper itself

Abstract

Glaucoma is a leading cause of irreversible visual impairment and blindness worldwide. Previous genome-wide association studies have identified caveolin-1 (CAV1), ATP-binding cassette A1 (ABCA1), and forkhead box C1 (FOXC1) loci associated with primary open angle glaucoma (POAG), a major subtype of glaucoma. This study aimed to fine map the association pattern of FOXC1 locus with POAG and determine the correlations of FOXC1, ABCA1, and CAV1 variants with ocular and lipidemic parameters in southern Chinese population. In total, 1291 unrelated Han Chinese subjects were recruited, including 301 high-tension glaucoma (HTG), 126 normal-tension glaucoma (NTG), and 864 control subjects. Twelve variants in FOXC1 locus, and two variants in ABCA1 and CAV1 genes, were genotyped by TaqMan assays. Genetic risk score and genotype-phenotype correlation analyses were conducted. In the FOXC1 locus, LOC102723944 rs6596830, rather than previously reported rs2745572, showed significant association with POAG (P = 8.61 × 10

Indexed as

ATP Binding Cassette Transporter 1Glaucoma, Open-AngleLow Tension GlaucomaCase-Control StudiesEast Asian PeopleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideABCA1 protein, humanATP Binding Cassette Transporter 1ABCA1FOXC1Genotype–phenotype correlationPrimary open angle glaucoma

Identifiers

PMID37516687
OpenAlexW4385379540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.