Evidence map›Paper›PMID 37516686›Full record

ArticleEndocrine2023

Potential impact of obesity on the aggressiveness of low- to intermediate-risk papillary thyroid carcinoma: results from a MASTER cohort study.

Mijin Kim, Yae Eun Kang, Young Joo Park, Bon Seok Koo, Eu Jeong Ku, June Young Choi, Eun Kyung Lee, Bo Hyun Kim

Abstract read
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Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mijin Kim *Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Yae Eun Kang *Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
Young Joo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Bon Seok KooDepartment of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Eu Jeong KuDepartment of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
June Young ChoiDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Eun Kyung LeeCenter for Thyroid Cancer, National Cancer Center, Goyang, Republic of Korea. eklee@ncc.re.kr.
Bo Hyun KimDepartment of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea. pons71@hanmail.net.ORCID 0000-0001-9632-9457

Funding

Ministry of Health and Welfare HI19C0481, HC19C0103
6 · The paper itself

Abstract

purposeObesity is associated with an increased risk of papillary thyroid carcinoma (PTC). Evidence of the impact of obesity on PTC aggressiveness is scarce. We aimed to evaluate the association between the body mass index (BMI) and the presence of aggressive features of low- to intermediate-risk PTC in a prospective cohort.

methodsWe prospectively enrolled 1,032 patients with low- to intermediate-risk PTC who underwent lobectomy at 22 hospitals in Korea and divided into three groups according to BMI, as follows: normal/underweight ( < 23 kg/m

resultsObese patients had a higher rate of macro-PTC ( > 1 cm) and greater incidence of extra-thyroidal extension (ETE), vascular invasion, and intermediate-risk tumors than those not classified as obese. Increased BMI was positively associated with the incidence of macro-PTC, ETE, vascular invasion, and intermediate-risk category. After adjusting for age, sex, pathological features, metabolic syndrome, thyroid function test, and smoking habits, obesity was a risk factor for ETE (odds ratio [OR] = 1.7, 95% confidence interval [CI]: 1.2-2.5, p = 0.005) and intermediate-risk PTC (OR = 1.7, 95% CI: 1.1-2.5, p = 0.011) in women. The association between obesity and ETE was significant regardless of whether or not women had metabolic syndrome. There was no significant association between obesity and aggressive PTC features in men.

conclusionBMI at the time of thyroid cancer diagnosis may affect the aggressiveness of low- to intermediate-risk PTC, especially in women.

Indexed as

Carcinoma, PapillaryMetabolic SyndromeThyroid NeoplasmsCohort StudiesHumansMaleObesityProspective StudiesRetrospective StudiesThyroid Cancer, PapillaryThyroidectomyAggressivenessBody mass indexMetabolic syndromeObesityPapillary thyroid carcinoma

Identifiers

PMID37516686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.