Evidence map›Paper›PMID 37516679›Full record

ReviewJournal of the Association for Research in Otolaryngology : JARO2023

The Next Challenges of Vestibular Implantation in Humans.

Joost Johannes Antonius Stultiens, Richard F Lewis, James O Phillips, Anissa Boutabla, Charles C Della Santina, Rudolf Glueckert, Raymond van de Berg

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the Association for Research in Otolaryngology : JARO, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Investigation of Vestibular Dysfunction Requires Renewed Research Enthusiasm.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Pooled it
  2. Rapid acclimatization to baseline stimulation with a multi-canal vestibulocochlear implant.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Trial
  3. Preserving the Membranous Labyrinth With a Piezoelectric Drill? Exploring Potential for Semicircular Canal Surgery.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
    Article
  4. Review
  5. Effects of Electrode Position on Vestibular Implant Performance in Rhesus Macaque.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Article
  6. Exploring the role of the electrically evoked Vestibulo-Ocular reflex in vestibular implant surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. A Hand-Guided Robotic Drill for Vestibular Implant Surgery-Feasibility of Preventing Membranous Labyrinth Rupture.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
  17. Vestibular Implant Surgery: How to Deal With Obstructed Semicircular Canals-A Diagnostic and Surgical Guide.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Joost Johannes Antonius StultiensDepartment of Otorhinolaryngology & Head and Neck Surgery, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, P. Debyelaan 25, Maastricht, 6202 AZ, The Netherlands. joost.stultiens@mumc.nl.ORCID http://orcid.org/0000-0003-3691-3912
Richard F LewisDepartment of Otolaryngology and Neurology, Harvard Medical School, Boston, MA, USA.
James O PhillipsDepartment of Otolaryngology, University of Washington, Seattle, WA, USA.
Anissa BoutablaDepartment of Otorhinolaryngology & Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Charles C Della SantinaDepartment of Biomedical Engineering and Department of Otolaryngology - Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Rudolf GlueckertDepartment of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
Raymond van de BergDepartment of Otorhinolaryngology & Head and Neck Surgery, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, P. Debyelaan 25, Maastricht, 6202 AZ, The Netherlands.
Harvard University · USInnsbruck Medical University · ATJohns Hopkins University · USMaastricht University Medical Centre · NLUniversity Hospital of Geneva · CHUniversity Medical Center · USUniversity of Washington · US

Funding

Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular HypofunctionU01DC019364 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Charles C Della Santina · 2021 to 2026
$2.9M
Vestibular implantation in older adultsR01AG076701 · NIA · JOHNS HOPKINS UNIVERSITY · PI DELLA SANTINA, CHARLES C · 2022 to 2025
$2.1M
NIA NIH HHS R01 AG076701NIDCD NIH HHS U01 DC019364
6 · The paper itself

Abstract

Patients with bilateral vestibulopathy suffer from a variety of complaints, leading to a high individual and social burden. Available treatments aim to alleviate the impact of this loss and improve compensatory strategies. Early experiments with electrical stimulation of the vestibular nerve in combination with knowledge gained by cochlear implant research, have inspired the development of a vestibular neuroprosthesis that can provide the missing vestibular input. The feasibility of this concept was first demonstrated in animals and later in humans. Currently, several research groups around the world are investigating prototype vestibular implants, in the form of vestibular implants as well as combined cochlear and vestibular implants. The aim of this review is to convey the presentations and discussions from the identically named symposium that was held during the 2021 MidWinter Meeting of the Association for Research in Otolaryngology, with researchers involved in the development of vestibular implants targeting the ampullary nerves. Substantial advancements in the development have been made. Yet, research and development processes face several challenges to improve this neuroprosthesis. These include, but are not limited to, optimization of the electrical stimulation profile, refining the surgical implantation procedure, preserving residual labyrinthine functions including hearing, as well as gaining regulatory approval and establishing a clinical care infrastructure similar to what exists for cochlear implants. It is believed by the authors that overcoming these challenges will accelerate the development and increase the impact of a clinically applicable vestibular implant.

Indexed as

Bilateral VestibulopathyCochlear ImplantationCochlear ImplantsVestibule, LabyrinthAnimalsCochleaHumansBilateral vestibulopathyHumansVestibular implantVestibular neuroprosthesisVestibulopathy

Identifiers

PMID37516679
PMCPMC10504197
OpenAlexW4385382346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.