Evidence map›Paper›PMID 37516675›Full record

ArticleMolecular imaging and biology2024

Deuterium Magnetic Resonance Spectroscopy Quantifies Tumor Fraction in a Mouse Model of a Mixed Radiation Necrosis / GL261-Glioblastoma Lesion.

Kyu-Ho Song, Xia Ge, John Engelbach, Keith M Rich, Joseph J H Ackerman, Joel R Garbow

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. In vivoMagnetic resonance in medicine · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kyu-Ho SongDepartment of Radiology, Biomedical MR Center, Washington University, 660 South Euclid Avenue, MO 63110, St. Louis, MO, Mail Stop Code: MSC 8227-0082-02, USA.
Xia GeDepartment of Radiology, Biomedical MR Center, Washington University, 660 South Euclid Avenue, MO 63110, St. Louis, MO, Mail Stop Code: MSC 8227-0082-02, USA.
John EngelbachDepartment of Radiology, Biomedical MR Center, Washington University, 660 South Euclid Avenue, MO 63110, St. Louis, MO, Mail Stop Code: MSC 8227-0082-02, USA.
Keith M RichDepartment of Neurosurgery, Washington University, St. Louis, MO, USA.
Joseph J H AckermanDepartment of Radiology, Biomedical MR Center, Washington University, 660 South Euclid Avenue, MO 63110, St. Louis, MO, Mail Stop Code: MSC 8227-0082-02, USA.
Joel R GarbowDepartment of Radiology, Biomedical MR Center, Washington University, 660 South Euclid Avenue, MO 63110, St. Louis, MO, Mail Stop Code: MSC 8227-0082-02, USA. garbow@wustl.edu.ORCID 0000-0002-0654-2703
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

purposeDistinguishing recurrent brain tumor from treatment effects, including late time-to-onset radiation necrosis (RN), presents an on-going challenge in post-treatment imaging of neuro-oncology patients. Experiments were performed in a novel mouse model that recapitulates the relevant clinical histologic features of recurrent glioblastoma growing in a RN environment, the mixed tumor/RN model. The goal of this work was to apply single-voxel deuterium ( PROCEDURES:

resultsBased on previous work, the tumor fraction of the mixed lesion was quantified as the ratio of tumor volume, defined by

conclusionsThis preclinical study supports the proposal that

Indexed as

GlioblastomaAnimalsDeuteriumDisease Models, AnimalGlucoseHumansLactic AcidMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMiceNecrosisDeuteriumGlucoseLactic AcidDeuterium metabolic imagingDMIGBMGL261Radiation necrosisSingle voxel spectroscopy

Identifiers

PMID37516675
PMCPMC11151282
OpenAlexW4385379519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.