Evidence map›Paper›PMID 37516304›Full record

ArticleRegulatory toxicology and pharmacology : RTP2023

A multi-tiered hierarchical Bayesian approach to derive toxic equivalency factors for dioxin-like compounds.

Caroline Ring, Alexander Blanchette, William D Klaren, Seneca Fitch, Laurie Haws, Matthew W Wheeler, Michael DeVito, Nigel Walker, Daniele Wikoff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regulatory toxicology and pharmacology : RTP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Dioxins vs. PFAS: Science and Policy Challenges.Environmental health perspectives · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caroline RingToxStrategies, Austin, TX, USA. Electronic address: ring.caroline@epa.gov.
Alexander BlanchetteToxStrategies, Asheville, NC, USA. Electronic address: ablanchette@toxstrategies.com.
William D KlarenToxStrategies, Asheville, NC, USA. Electronic address: wklaren@toxstrategies.com.
Seneca FitchToxStrategies, Katy, TX, USA. Electronic address: sfitch@toxstrategies.com.
Laurie HawsToxStrategies, Austin, TX, USA. Electronic address: lhaws@toxstrategies.com.
Matthew W WheelerNational Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: matt.wheeler@nih.gov.
Michael DeVitoEnvironmental Protection Agency, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA. Electronic address: devito.michael@epa.gov.
Nigel WalkerNational Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: walker3@niehs.nih.gov.
Daniele WikoffToxStrategies, Asheville, NC, USA. Electronic address: dwikoff@toxstrategies.com.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

In 2005, the World Health Organization (WHO) re-evaluated Toxic Equivalency factors (TEFs) developed for dioxin-like compounds believed to act through the Ah receptor based on an updated database of relative estimated potency (REP)(REP

Indexed as

DioxinsPolychlorinated BiphenylsBayes TheoremReceptors, Aryl HydrocarbonRisk AssessmentUncertaintyDioxinsPolychlorinated BiphenylsReceptors, Aryl Hydrocarbon

Identifiers

PMID37516304
PMCPMC11110530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.