Evidence map›Paper›PMID 37516290›Full record

ArticleArchives of biochemistry and biophysics2023

The DUSP domain of pseudophosphatase MK-STYX interacts with G3BP1 to decrease stress granules.

Jonathan Smailys, Fei Jiang, Tatiana Prioleau, Kylan Kelley, Olivia Mitchell, Samah Nour, Lina Ali, William Buchser, Lynn Zavada, Shantá D Hinton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jonathan SmailysDepartment of Biology, Integrated Science Center, William and Mary, Williamsburg, VA, 23185, USA.
Fei JiangDepartment of Biology, Integrated Science Center, William and Mary, Williamsburg, VA, 23185, USA.
Tatiana PrioleauDepartment of Biology, Integrated Science Center, William and Mary, Williamsburg, VA, 23185, USA.
Kylan KelleyDepartment of Biology, Integrated Science Center, William and Mary, Williamsburg, VA, 23185, USA; Department of Genetics, Washington University, St. Louis, MO, 63110, USA.
Olivia MitchellDepartment of Biology, Hampton University, Hampton, VA, 23666, USA.
Samah NourDepartment of Genetics, Washington University, St. Louis, MO, 63110, USA.
Lina AliDepartment of Genetics, Washington University, St. Louis, MO, 63110, USA.
William BuchserDepartment of Genetics, Washington University, St. Louis, MO, 63110, USA.
Lynn ZavadaDepartment of Biology, Integrated Science Center, William and Mary, Williamsburg, VA, 23185, USA.
Shantá D HintonDepartment of Biology, Integrated Science Center, William and Mary, Williamsburg, VA, 23185, USA. Electronic address: sdhinton@wm.edu.
William & Mary · USWashington University in St. Louis · USHampton University · US

Funding

Pseudophosphatase MK-STYX: A Signaling Molecule for DifferentiationR15NS115074 · NINDS · COLLEGE OF WILLIAM AND MARY · PI HINTON, SHANTA' D · 2020 to 2022
$500k
NINDS NIH HHS R15 NS115074
6 · The paper itself

Abstract

Mitogen activated protein kinase phosphoserine/threonine/tyrosine-binding protein (MK-STYX) is a dual specificity (DUSP) member of the protein tyrosine phosphatase family. It is a pseudophosphatase, which lacks the essential amino acids histidine and cysteine in the catalytic active signature motif (HCX

Indexed as

DNA HelicasesStress GranulesApoptosis Regulatory ProteinsHeLa CellsHumansIntracellular Signaling Peptides and ProteinsPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsTyrosineApoptosis Regulatory ProteinsDNA HelicasesG3BP1 protein, humanIntracellular Signaling Peptides and ProteinsPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsSTYXL1 protein, humanTyrosineCell division cycle 25 phosphatase homology 2Dual specificity domainG3BP1MK-STYXProtein tyrosine phosphatasePseudophosphataseStress granules

Identifiers

PMID37516290
PMCPMC10500436
OpenAlexW4385310177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.