ArticleImmunity2023
Ketolysis drives CD8
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Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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90citing papers in PubMed
19.3field-weighted citation impact, top 1% of its field
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Who cites it
90 citing papers in PubMed, 110 citations in OpenAlex.
- Time-restricted eating, immunomodulation and ketone metabolism in humans.Metabolism: clinical and experimental · 2026Review
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Ketone signaling goes nuclear.Nature chemical biology · 2026Article
- FASTINA - protocol for a randomised feasibility trial of time-restricted eating to improve response to multiple myeloma therapy.Pilot and feasibility studies · 2026Article
- Immunometabolic Effects of SGLT2 Inhibitors on the Th17/Treg Axis: Mechanisms, Evidence, and Implications for Therapeutic Repurposing.Molecular biology reports · 2026Review
- Ketogenic Diet as an Adjuvant in Epithelial Cancers: Mechanisms, Model Systems, and Translational Opportunities.Cancers · 2026Review
- Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma.Nature communications · 2026Article
- Acetoacetate-GPR43 axis epigenetically silences IL-6/CSF1 to restrict TAMs-driven metastatic lung cancer.Journal of translational medicine · 2026Article
- Endogenous metabolite signaling orchestrates tumor immune evasion.Cell insight · 2026Review
- The interplay between lipid metabolism, cancer progression and anti-cancer immunity.Experimental & molecular medicine · 2026Review
- Article
- Ketone body metabolism activates the immune response againstCell insight · 2026Article
- β-hydroxybutyrate potentiates anti-tumor immunity by modulating cytotoxic CD8Cancer immunology, immunotherapy : CII · 2026Article
- Metabolic and transcriptional plasticity supports CD8Immunity · 2026Article
- Review
- The advent of precision nutrigeroscience in cancer: from clinic towards molecular biology.Journal of advanced research · 2026Review
- Ketone ester supplementation in aged mice reduces activation of B cell subsets.bioRxiv : the preprint server for biology · 2026Article
- The value of targeting ketone body metabolism in inflammatory and autoimmune diseases.Journal of translational medicine · 2026Review
- Effect of Oral Ketone Body Intake on Human CD8Nutrients · 2026Article
- Quantifying endogenous and tracer-derived ketone bodies using a dual-label UHPLC-MS/MS method.Talanta · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 5 institutions in 3 countries.
Katarzyna M LudaDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Blegdamsvej 3B, 2200 København, Denmark.
Joseph LongoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Susan M Kitchen-GoosenDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Lauren R DuimstraDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Eric H MaDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
McLane J WatsonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Brandon M OswaldDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Zhen FuBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Zachary MadajBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Ariana KupaiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Bradley M DicksonDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Lisa M DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Michael S DahabiehDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Shelby E ComptonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Robert TeisDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Irem KaymakDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Kin H LauBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Daniel P KellyCardiovascular Institute and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Patrycja PuchalskaDepartment of Medicine, Division of Molecular Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Kelsey S WilliamsDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Dominique LévesqueDepartment of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.
François-Michel BoisvertDepartment of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.
Ryan D SheldonMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Scott B RothbartDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Peter A CrawfordDepartment of Medicine, Division of Molecular Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: russell.jones@vai.org.
Van Andel Institute · USUniversité de Sherbrooke · CAUniversity of Minnesota · USCardiovascular Institute of the South · USUniversity of Copenhagen · DK
Funding
KETONE BODY METABOLISM AND INTEGRATED METABOLIC HOMEOSTASISR01DK091538 · NIDDK · WASHINGTON UNIVERSITY · PI CRAWFORD, PETER A · 2011 to 2024
$6.2MProbing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1MKetone Body Metabolism in CD8+ T Cell ResponsesR01AI165722 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI JONES, RUSSELL GRAHAM · 2022 to 2025
$3.3MTargeting Ketone Metabolism as a Novel Heart Failure TherapyR01HL151345 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KELLY, DANIEL PATRICK, RECCHIA, FABIO A · 2020 to 2023
$3.2MCancer Epigenetics Training (CET) ProgramT32CA251066 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Scott Rothbart · 2021 to 2026
$2.4MMolecular mechanisms of chromatin and epigenetic regulationR35GM124736 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI ROTHBART, SCOTT · 2017 to 2021
$2.4MKetogenic Oscillations and Neurometabolic HealthspanR01AG069781 · NIA · UNIVERSITY OF MINNESOTA · PI CRAWFORD, PETER A, THYFAULT, JOHN P · 2020 to 2024
$2.3MChromatin architecture as a determinant of dendritic cell functionR21AI153997 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI KRAWCZYK, CONNIE · 2020 to 2021
$523kNCI NIH HHS T32 CA251066NHLBI NIH HHS R01 HL128349NHLBI NIH HHS R01 HL151345NIAID NIH HHS R01 AI165722NIAID NIH HHS R21 AI153997NIA NIH HHS R01 AG069781NIDDK NIH HHS R01 DK091538NIGMS NIH HHS R35 GM124736
Abstract
Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8
Indexed as
CD8-Positive T-LymphocytesHistones3-Hydroxybutyric AcidAcetylationAnimalsKetone BodiesMice3-Hydroxybutyric AcidHistonesKetone Bodiesacetyl-CoAcancer immunologyCD8(+) T cellseffector functionepigeneticsketolysisketone bodiesmetabolismTCA cycle
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