Evidence map›Paper›PMID 37515733›Full record

ArticleJournal of neurology2023

Pre-treatment risk markers for hemorrhagic transformation in posterior circulation acute ischemic stroke treated with reperfusion therapy.

Claire Ancelet, Sophie Neveü, Laura Venditti, Jonathan Cortese, Oliver Chassin, Coralie Pelissou, Elsa Talab Berthou, Matthias Babin, Ghaidaa Nasser, Farida Benoudiba and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Claire AnceletDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France. claire.ancelet@aphp.fr.ORCID http://orcid.org/0000-0002-0205-5721
Sophie NeveüDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Laura VendittiDepartment of Neurology, Hôpital Bicêtre, Stroke Center, 78 Rue du General Leclerc, 94270, Le Kremlin Bicêtre, France.
Jonathan CorteseDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Oliver ChassinDepartment of Neurology, Hôpital Bicêtre, Stroke Center, 78 Rue du General Leclerc, 94270, Le Kremlin Bicêtre, France.
Coralie PelissouDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Elsa Talab BerthouDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Matthias BabinDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Ghaidaa NasserDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Farida BenoudibaDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Nicolas LegrisDepartment of Neurology, Hôpital Bicêtre, Stroke Center, 78 Rue du General Leclerc, 94270, Le Kremlin Bicêtre, France.
Mariana Sarov RivièreDepartment of Neurology, Hôpital Bicêtre, Stroke Center, 78 Rue du General Leclerc, 94270, Le Kremlin Bicêtre, France.
Nicolas ChaussonParis-Saclay University Faculty of Medicine, INSERM U1195, Le Kremlin-Bicêtre, France.
Laurent SpelleDiagnostic and Interventional Neuroradiology Department, NEURI Brain Vascular Center, Bicêtre University-Hospital, 78 Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Christian DenierDepartment of Neurology, Hôpital Bicêtre, Stroke Center, 78 Rue du General Leclerc, 94270, Le Kremlin Bicêtre, France.
Bicêtre Hospital · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemorrhagic transformation (HT) is an uncommon complication of posterior circulation acute ischemic stroke (PCS) compared to anterior circulation stroke. Nevertheless, it remains a major concern especially following reperfusion therapy. This study aimed at identifying potential predictive factors associated with HT in PCS.

methodsConsecutive patients, from a multicenter cohort, with PCS treated by IVT or EVT or the combination of both, were included from December 2015 to May 2019. The European Cooperative Acute Stroke Study criteria was used to identify HT. Potential risk factors were analyzed using univariate and multivariable testing models.

resultsA total of 96 patients were included in our study. Median age was 66 (57-83) years, 54 patients (56%) were male and median baseline NIHSS was 8 (4-14). 77 patients (80%) received IVT and 54 patients (56%) benefited from EVT. HT occurred in 19 patients (20%), while sHT occurred in 3 patients (3%). HT was found to be associated with poor functional status at 3 months in univariate analysis (p = 0.0084). Multivariable analysis confirmed that higher baseline NIHSS (OR 1.1008; 95% CI [1.0216-1.1862]; p = 0.0117) and lobar topography of ischemia (OR 4.4275; 95% CI [1.3732-14.2753]; p = 0.0127) were independent predictors of the occurrence of HT. DISCUSSION: HT is associated with increased morbidity in patients with PCS; higher NIHSS and lobar ischemia were independent predictors of HT in our population. Easy-to-use predictive markers may help to tailor therapeutic management of patients with PCS.

Indexed as

Cerebral HemorrhageEndovascular ProceduresIntracranial HemorrhagesIschemic StrokeReperfusionThrombolytic TherapyAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsIschemic strokePredictive factorsSymptomatic intracranial hemorrhageThrombectomy

Identifiers

PMID37515733
OpenAlexW4385381870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.