Evidence map›Paper›PMID 37515710›Full record

ArticleHormones (Athens, Greece)2024

Patients with Hashimoto's thyroiditis present higher immune response to COVID-19 mRNA vaccine compared to normal individuals.

Antonis Polymeris, Petros D Papapetrou, Stavroula Psachna, Dimitrios Ioannidis, Dimitrios Lilis, Maria Drakou, Aristeidis Vaiopoulos, Vaia Polymerou, Georgios Spanos

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Article in Hormones (Athens, Greece), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Antonis PolymerisDepartment of Endocrinology, Metabolism and Diabetes Mellitus, Sismanogleio-Amalia Fleming General Hospital, 25th Martiou Str. 14, Melissia 15127, Athens, Greece. antonispolymeris@gmail.com.ORCID http://orcid.org/0000-0002-7402-3825
Petros D PapapetrouDepartment of Endocrinology, Metabolism and Diabetes Mellitus, Sismanogleio-Amalia Fleming General Hospital, 25th Martiou Str. 14, Melissia 15127, Athens, Greece.
Stavroula PsachnaDepartment of Endocrinology, Metabolism and Diabetes Mellitus, Sismanogleio-Amalia Fleming General Hospital, 25th Martiou Str. 14, Melissia 15127, Athens, Greece.
Dimitrios IoannidisDepartment of Endocrinology, Metabolism and Diabetes Mellitus, Sismanogleio-Amalia Fleming General Hospital, 25th Martiou Str. 14, Melissia 15127, Athens, Greece.
Dimitrios LilisDepartment of Endocrinology, Metabolism and Diabetes Mellitus, Sismanogleio-Amalia Fleming General Hospital, 25th Martiou Str. 14, Melissia 15127, Athens, Greece.
Maria DrakouDepartment of Endocrinology, Metabolism and Diabetes Mellitus, Sismanogleio-Amalia Fleming General Hospital, 25th Martiou Str. 14, Melissia 15127, Athens, Greece.
Aristeidis VaiopoulosSecond Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Atticon" University General Hospital, Athens, Greece.
Vaia Polymerou"Bioiatriki" Healthcare Group, Athens, Greece.
Georgios Spanos"Bioiatriki" Healthcare Group, Athens, Greece.
Athens Medical Center · GRNational and Kapodistrian University of Athens · GRSimanogleio-Amalia Fleming General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the response (titers of anti-COVID-19 antibodies) to COVID-19 mRNA vaccine of patients with Hashimoto's thyroiditis and normal individuals. PATIENTS AND

methodsTwenty-four patients with Hashimoto's thyroiditis and 51 normal individuals were studied after the third dose of the vaccine.

resultsPatients with Hashimoto's thyroiditis showed significantly higher immune response after the third dose of the COVID-19 mRNA vaccine compared with normal individuals (p = 0.020). After elimination of the four smokers with Hashimoto's thyroiditis, the immune response between the remaining 20 non-smoking patients compared with the response of the 23 non-smoking normal individuals was not different (p = 0.564). There was a significant positive correlation of the anti-COVID-19 antibodies with BMI (p = 0.029) but not with waist circumference in the patients with Hashimoto's thyroiditis (p = 0.054). Similar correlations were not found in normal individuals. Waist circumference could be considered as representative of visceral adipose tissue. In obese normal individuals (BMI ≥ 30), anti-COVID-19 antibodies were not different from those in lean normal individuals (BMI < 25). In obese patients with Hashimoto's thyroiditis, anti-COVID-19 antibodies were significantly higher compared to those in lean patients (p = 0.013). Median anti-COVID-19 antibody titer in obese patients with Hashimoto's thyroiditis was also significantly higher compared to that in obese normal individuals (p = 0.009).

conclusionsPatients with Hashimoto's thyroiditis show significantly higher immune response after the third dose of the COVID-19 mRNA vaccine compared with normal individuals. Obese patients with Hashimoto's thyroiditis show additionally a significantly higher immune response compared with lean patients.

Indexed as

COVID-19Hashimoto DiseaseCOVID-19 VaccinesHumansImmunitymRNA VaccinesObesityCOVID-19 VaccinesmRNA VaccinesAnti-COVID-19 antibodiesCOVID-19 mRNA vaccineHashimoto’s thryroiditisOverweight-obese patients

Identifiers

PMID37515710
OpenAlexW4385380397

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.