Evidence map›Paper›PMID 37515411›Full record

ArticleVeterinary pathology2023

Automated diagnosis of 7 canine skin tumors using machine learning on H&E-stained whole slide images.

Marco Fragoso-Garcia, Frauke Wilm, Christof A Bertram, Sophie Merz, Anja Schmidt, Taryn Donovan, Andrea Fuchs-Baumgartinger, Alexander Bartel, Christian Marzahl, Laura Diehl and 5 more

Abstract read
In one paragraph

Article in Veterinary pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Artificial intelligence predictsVeterinary pathology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review of Molecular Technologies for Investigating Canine Cancer.Animals : an open access journal from MDPI · 2024
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marco Fragoso-GarciaFreie Universität, Berlin, Germany.
Frauke WilmFriedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-9065-0554
Christof A BertramUniversity of Veterinary Medicine, Vienna, Austria.ORCID 0000-0002-2402-9997
Sophie MerzIDEXX GmbH, Kornwestheim, Germany.
Anja SchmidtIDEXX GmbH, Kornwestheim, Germany.
Taryn DonovanSchwarzman Animal Medical Center, New York, NY.ORCID 0000-0001-5740-9550
Andrea Fuchs-BaumgartingerUniversity of Veterinary Medicine, Vienna, Austria.
Alexander BartelFreie Universität, Berlin, Germany.ORCID 0000-0002-1280-6138
Christian MarzahlFriedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Laura DiehlFreie Universität, Berlin, Germany.
Chloe PugetFreie Universität, Berlin, Germany.
Andreas MaierFriedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Marc AubrevilleTechnische Hochschule Ingolstadt, Ingolstadt, Germany.ORCID 0000-0002-5294-5247
Katharina BreiningerFriedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Robert KlopfleischFreie Universität, Berlin, Germany.ORCID 0000-0002-6308-0568

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microscopic evaluation of hematoxylin and eosin-stained slides is still the diagnostic gold standard for a variety of diseases, including neoplasms. Nevertheless, intra- and interrater variability are well documented among pathologists. So far, computer assistance via automated image analysis has shown potential to support pathologists in improving accuracy and reproducibility of quantitative tasks. In this proof of principle study, we describe a machine-learning-based algorithm for the automated diagnosis of 7 of the most common canine skin tumors: trichoblastoma, squamous cell carcinoma, peripheral nerve sheath tumor, melanoma, histiocytoma, mast cell tumor, and plasmacytoma. We selected, digitized, and annotated 350 hematoxylin and eosin-stained slides (50 per tumor type) to create a database divided into training,

Indexed as

Deep LearningDog DiseasesSkin NeoplasmsAnimalsArtificial IntelligenceDogsEosine Yellowish-(YS)HematoxylinMachine LearningReproducibility of ResultsEosine Yellowish-(YS)Hematoxylincomputational pathologycomputer-aided diagnosisdigital pathologydogmachine learningskinveterinary oncology

Identifiers

PMID37515411
PMCPMC10583479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.