Evidence map›Paper›PMID 37515289›Full record

ArticleViruses2023

SARS-CoV-2 Serological Investigation of White-Tailed Deer in Northeastern Ohio.

Patricia A Boley, Patricia M Dennis, Julia N Faraone, Jiayu Xu, Mingde Liu, Xiaoyu Niu, Stormy Gibson, Vanessa Hale, Qiuhong Wang, Shan-Lu Liu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Patricia A BoleyCenter for Food Animal Health, The Ohio State University College of Food, Agriculture and Environmental Sciences, Wooster, OH 44691, USA.ORCID 0000-0001-9356-5630
Patricia M DennisVeterinary Preventative Medicine, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.
Julia N FaraoneVeterinary Preventative Medicine, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.
Jiayu XuCenter for Food Animal Health, The Ohio State University College of Food, Agriculture and Environmental Sciences, Wooster, OH 44691, USA.
Mingde LiuCenter for Food Animal Health, The Ohio State University College of Food, Agriculture and Environmental Sciences, Wooster, OH 44691, USA.
Xiaoyu NiuCenter for Food Animal Health, The Ohio State University College of Food, Agriculture and Environmental Sciences, Wooster, OH 44691, USA.
Stormy GibsonOhio Department of Natural Resources Division of Wildlife, Columbus, OH 43299, USA.
Vanessa HaleVeterinary Preventative Medicine, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.ORCID 0000-0002-8531-7001
Qiuhong WangCenter for Food Animal Health, The Ohio State University College of Food, Agriculture and Environmental Sciences, Wooster, OH 44691, USA.ORCID 0000-0002-8238-417X
Shan-Lu LiuVeterinary Preventative Medicine, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.ORCID 0000-0003-1620-3817
Linda J SaifCenter for Food Animal Health, The Ohio State University College of Food, Agriculture and Environmental Sciences, Wooster, OH 44691, USA.ORCID 0000-0002-3224-9009
Scott P KenneyCenter for Food Animal Health, The Ohio State University College of Food, Agriculture and Environmental Sciences, Wooster, OH 44691, USA.ORCID 0000-0002-7449-2066
The Ohio State University · USCleveland Metroparks Zoo · USOhio Department of Natural Resources · US

Funding

Project 3: Responding to Changing Serological and Viral Information around COVID-19 (RESPOND)U54CA260582 · NCI · OHIO STATE UNIVERSITY · PI MCALEARNEY, ANN SCHECK, OLTZ, EUGENE M · 2020 to 2024
$10.4M
NCI NIH HHS U54 CA260582NIH HHS U54CA260582
6 · The paper itself

Abstract

Coronaviruses are known to cross species barriers, and spill over among animals, from animals to humans, and vice versa. SARS-CoV-2 emerged in humans in late 2019. It is now known to infect numerous animal species, including companion animals and captive wildlife species. Experimental infections in other animals have established that many species are susceptible to infection, with new ones still being identified. We have developed an enzyme-linked immunosorbent assay (ELISA) for detecting antibodies to SARS-CoV-2 nucleocapsid (N) and spike (S) proteins, that is both sensitive and specific. It can detect S antibodies in sera at dilutions greater than 1:10,000, and does not cross-react with antibodies to the other coronaviruses tested. We used the S antibody ELISA to test serum samples collected from 472 deer from ten sites in northeastern Ohio between November 2020 and March 2021, when the SARS-CoV-2 pandemic was first peaking in humans in Ohio, USA. Antibodies to SARS-CoV-2 were found in serum samples from every site, with an overall positivity rate of 17.2%; we further compared the viral neutralizing antibody titers to our ELISA results. These findings demonstrate the need to establish surveillance programs to monitor deer and other susceptible wildlife species globally.

Indexed as

COVID-19DeerAnimalsAnimals, WildAntibodies, ViralEnzyme-Linked Immunosorbent AssayHumansOhioSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19deerELISAOhioSARS-CoV-2seroprevalence

Identifiers

PMID37515289
PMCPMC10385782
OpenAlexW4385162076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.