Evidence map›Paper›PMID 37515241›Full record

ArticleViruses2023

The Cornell COVID-19 Testing Laboratory: A Model to High-Capacity Testing Hubs for Infectious Disease Emergency Response and Preparedness.

Melissa Laverack, Rebecca L Tallmadge, Roopa Venugopalan, Daniel Sheehan, Scott Ross, Rahim Rustamov, Casey Frederici, Kim S Potter, François Elvinger, Lorin D Warnick and 4 more

Abstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Melissa LaverackDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-3102-2088
Rebecca L TallmadgeDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-7466-5449
Roopa VenugopalanDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.
Daniel SheehanInformation Technology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Scott RossInformation Technology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Rahim RustamovDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.
Casey FredericiCayuga Medical Center, Cayuga Health System, Ithaca, NY 14850, USA.
Kim S PotterDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.
François ElvingerDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.
Lorin D WarnickDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.
Gary A KoretzkyDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Robert LawlisCayuga Medical Center, Cayuga Health System, Ithaca, NY 14850, USA.
Elizabeth PlocharczykCayuga Medical Center, Cayuga Health System, Ithaca, NY 14850, USA.
Diego G DielDepartment of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center (AHDC), College of Veterinary Medicine, Cornell COVID-19 Testing Laboratory (CCTL), Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-3237-8940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unprecedented COVID-19 pandemic posed major challenges to local, regional, and global economies and health systems, and fast clinical diagnostic workflows were urgently needed to contain the spread of SARS-CoV-2. Here, we describe the platform and workflow established at the Cornell COVID-19 Testing Laboratory (CCTL) for the high-throughput testing of clinical samples from the university and the surrounding community. This workflow enabled efficient and rapid detection and the successful control of SARS-CoV-2 infection on campus and its surrounding communities. Our cost-effective and fully automated workflow enabled the testing of over 8000 pooled samples per day and provided results for over 2 million samples. The automation of time- and effort-intensive sample processing steps such as accessioning and pooling increased laboratory efficiency. Customized software applications were developed to track and store samples, deconvolute positive pools, track and report results, and for workflow integration from sample receipt to result reporting. Additionally, quality control dashboards and turnaround-time tracking applications were built to monitor assay and laboratory performance. As infectious disease outbreaks pose a constant threat to both human and animal health, the highly effective workflow implemented at CCTL could be modeled to establish regional high-capacity testing hubs for infectious disease preparedness and emergency response.

Indexed as

Communicable DiseasesCOVID-19Clinical Laboratory TechniquesCOVID-19 TestingHumansPandemicsSARS-CoV-2COVID-19diagnostic workflowSARS-CoV-2surveillance

Identifiers

PMID37515241
PMCPMC10385863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.