Evidence map›Paper›PMID 37515190›Full record

ReviewViruses2023

An Overview of the Conventional and Novel Methods Employed for SARS-CoV-2 Neutralizing Antibody Measurement.

Vinícius Pinto Costa Rocha, Helenita Costa Quadros, Antônio Márcio Santana Fernandes, Luana Pereira Gonçalves, Roberto José da Silva Badaró, Milena Botelho Pereira Soares, Bruna Aparecida Souza Machado

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Cancer and COVID-19: A review of immune insights and partnerships to inform public health strategy.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Vaccination versus natural infection: A review of antibody differentiation techniques.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vinícius Pinto Costa RochaInstitute of Health Technology, National Industrial Learning Service-Integrated Manufacturing and Technology Campus, SENAI CIMATEC, Salvador 41650-010, Bahia, Brazil.ORCID 0000-0002-5309-5950
Helenita Costa QuadrosLaboratory of Tissue Engineering and Immunopharmacology, Oswaldo Cruz Foundation, Gonçalo Moniz Institute-Fiocruz, Salvador 40296-710, Bahia, Brazil.ORCID 0000-0002-7191-4809
Antônio Márcio Santana FernandesInstitute of Health Technology, National Industrial Learning Service-Integrated Manufacturing and Technology Campus, SENAI CIMATEC, Salvador 41650-010, Bahia, Brazil.ORCID 0000-0001-8839-3395
Luana Pereira GonçalvesInstitute of Health Technology, National Industrial Learning Service-Integrated Manufacturing and Technology Campus, SENAI CIMATEC, Salvador 41650-010, Bahia, Brazil.ORCID 0009-0009-8793-3658
Roberto José da Silva BadaróInstitute of Health Technology, National Industrial Learning Service-Integrated Manufacturing and Technology Campus, SENAI CIMATEC, Salvador 41650-010, Bahia, Brazil.ORCID 0000-0002-2861-5061
Milena Botelho Pereira SoaresInstitute of Health Technology, National Industrial Learning Service-Integrated Manufacturing and Technology Campus, SENAI CIMATEC, Salvador 41650-010, Bahia, Brazil.
Bruna Aparecida Souza MachadoInstitute of Health Technology, National Industrial Learning Service-Integrated Manufacturing and Technology Campus, SENAI CIMATEC, Salvador 41650-010, Bahia, Brazil.
Serviço Nacional de Aprendizagem Industrial · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 is the etiological agent of the coronavirus disease-19 (COVID-19) and is responsible for the pandemic that started in 2020. The virus enters the host cell through the interaction of its spike glycoprotein with the angiotensin converting enzyme-2 (ACE2) on the host cell's surface. Antibodies present an important role during the infection and pathogenesis due to many reasons, including the neutralization of viruses by binding to different spike epitopes. Therefore, measuring the neutralizing antibody titers in the whole population is important for COVID-19's epidemiology. Different methods are described in the literature, and some have been used to validate the main vaccines used worldwide. In this review, we discuss the main methods used to quantify neutralizing antibody titers, their advantages and limitations, as well as new approaches to determineACE2/spike blockage by antibodies.

Indexed as

COVID-19SARS-CoV-2Antibodies, NeutralizingAntibodies, ViralHumansPeptidyl-Dipeptidase ASpike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralPeptidyl-Dipeptidase ASpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19neutralization testneutralizing antibodiesSARS-CoV-2

Identifiers

PMID37515190
PMCPMC10383723
OpenAlexW4383227214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.