Evidence map›Paper›PMID 37515166›Full record

ArticleViruses2023

Equine Polyclonal Antibodies Prevent Acute Chikungunya Virus Infection in Mice.

Douglas Barker, Xiaobing Han, Eryu Wang, Ashley Dagley, Deborah M Anderson, Aruni Jha, Scott C Weaver, Justin Julander, Cory Nykiforuk, Shantha Kodihalli

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Douglas BarkerEmergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.
Xiaobing HanEmergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.
Eryu WangInstitute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, Galveston, TX 77555, USA.
Ashley DagleyInstitute for Antiviral Research, Utah State University, Logan, UT 84322, USA.
Deborah M AndersonEmergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.
Aruni JhaEmergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.
Scott C WeaverInstitute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, Galveston, TX 77555, USA.ORCID 0000-0001-8016-8556
Justin JulanderInstitute for Antiviral Research, Utah State University, Logan, UT 84322, USA.
Cory NykiforukEmergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.
Shantha KodihalliEmergent BioSolutions Canada Inc., Winnipeg, MB R3T 5Y3, Canada.
Emergent BioSolutions (Canada) · CAThe University of Texas Medical Branch at Galveston · USUtah State University · US

Funding

World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
NIAID NIH HHS HHSN272201700041INIAID NIH HHS R24 AI120942NIH HHS AI120942
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is a mosquito-transmitted pathogen that causes chikungunya disease (CHIK); the disease is characterized by fever, muscle ache, rash, and arthralgia. This arthralgia can be debilitating and long-lasting, seriously impacting quality of life for years. Currently, there is no specific therapy available for CHIKV infection. We have developed a despeciated equine polyclonal antibody (CHIKV-EIG) treatment against CHIKV and evaluated its protective efficacy in mouse models of CHIKV infection. In immunocompromised (IFNAR

Indexed as

Chikungunya FeverChikungunya virusAnimalsAntibodies, ViralArthralgiaHorsesHumansMiceQuality of LifeViremiaAntibodies, Viralchikungunyamouse modelpharmacodynamics

Identifiers

PMID37515166
PMCPMC10384969
OpenAlexW4382787414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.