Evidence map›Paper›PMID 37515158›Full record

ArticleViruses2023

Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation.

Riley M Horvath, Ivan Sadowski

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Riley M HorvathMolecular Epigenetics Group, Department of Biochemistry and Molecular Biology, LSI, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.ORCID 0000-0002-8557-5406
Ivan SadowskiMolecular Epigenetics Group, Department of Biochemistry and Molecular Biology, LSI, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
University of British Columbia · CA

Funding

CIHR F16-01210
6 · The paper itself

Abstract

HIV-1 provirus expression is controlled by signaling pathways that are responsive to T cell receptor engagement, including those involving Ras and downstream protein kinases. The induction of transcription from the HIV-1 LTR in response to Ras signaling requires binding of the Ras-responsive element binding factor (RBF-2) to conserved

Indexed as

HIV-1Gene Expression RegulationReceptors, Antigen, T-CellT-LymphocytesUpstream Stimulatory FactorsReceptors, Antigen, T-CellUpstream Stimulatory FactorsepigeneticsHIV-1immuneinflammationlatencyLTRRBF-2T cell activationtranscriptionUSF1USF2

Identifiers

PMID37515158
PMCPMC10384547
OpenAlexW4382721605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.