Evidence map›Paper›PMID 37515136›Full record

ArticleViruses2023

Lack of Evidence for a Role of ACE-2 Polymorphisms as a Bedside Clinical Prognostic Marker of COVID-19.

Josè R Fiore, Mariantonietta Di Stefano, Andrew Oler, Yu Zhang, Jingwen Gu, Clifton L Dalgard, Giuseppina Faleo, Brian Epling, Luigi Notarangelo, Andrea Lisco and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Josè R FioreInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Mariantonietta Di StefanoInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0001-8814-0953
Andrew OlerBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6310-0434
Yu ZhangImmune Deficiency Genetics Disease Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease (NIAID), Division of Intramural Research (DIR), National Institutes of Health, Bethesda, MD 20892, USA.
Jingwen GuBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Clifton L DalgardCollaborative Health Initiative Research Program, The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20892, USA.
Giuseppina FaleoInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0001-5969-3890
Brian EplingNational Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Luigi NotarangeloImmune Deficiency Genetics Disease Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease (NIAID), Division of Intramural Research (DIR), National Institutes of Health, Bethesda, MD 20892, USA.
Andrea LiscoNational Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1475-356X
Teresa A SantantonioInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-4342-6904
National Institutes of Health · USUniversity of Foggia · ITUniformed Services University of the Health Sciences · US

Funding

Identification of immunological predictors of COVID-19 clinical outcomesZIAAI001309 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LISCO, ANDREA · 2020 to 2024
$107k
6 · The paper itself

Abstract

The novel SARS-CoV-2 coronavirus causes a severe respiratory syndrome referred to as coronavirus disease (COVID-19). The angiotensin-converting enzyme 2 (ACE-2) plays an important role as a cellular receptor for SARS-CoV-2 and is largely expressed in lungs, kidneys, heart and the gastrointestinal tract along with being shed in plasma. The ACE-2 gene and protein show a high level of genetic polymorphism, including simple nucleotide variation, transcriptional variation, post-transcriptional changes, and putative protein mutations that could interfere with the binding or entry of SARS-CoV-2 and affect tissue damage in lungs or other organs. Genetic polymorphisms can impact SARS-CoV-2 viral entry and COVID-19 severity. This single-center study evaluated the possible role of the main ACE-2 polymorphisms (rs143936283, rs2285666, rs41303171, rs35803318, and rs2106809) as potential prognostic markers in SARS-CoV-2-infected individuals. Frozen whole blood was used for DNA isolation and genomic DNA samples were sheared using the Covaris LE220 Focused-ultrasonicator for targeting a peak size of 410 bp. Whole-genome sequencing libraries were generated from fragmented DNA using the Illumina TruSeq DNA PCR-Free HT Library Preparation Kit and sequenced on an Illumina NovaSeq 6000. We did not identify any correlation between ACE-2 polymorphisms and COVID-19 prognosis, suggesting that the interpretation and clinical use of ACE-2 genetic polymorphisms in real-world clinical settings requires further experimental and clinical validation.

Indexed as

COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2BiomarkersHumansPolymorphism, GeneticPrognosisACE2 protein, humanAngiotensin-Converting Enzyme 2Biomarkersangiotensin-converting enzyme 2 (ACE-2)respiratory distress syndrome (ARDS)severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)single nucleotide polymorphism (SNP)

Identifiers

PMID37515136
PMCPMC10383962
OpenAlexW4382403174

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.