Evidence map›Paper›PMID 37515030›Full record

ArticleVaccines2023

Cellular and Humoral Immune Responses after Breakthrough Infection in Patients Undergoing Hemodialysis.

Masataro Toda, Ayumi Yoshifuji, Tetsuo Nakayama, Setsuko Mise-Omata, Emi Oyama, Yoshifumi Uwamino, Ho Namkoong, Motoaki Komatsu, Akihiko Yoshimura, Naoki Hasegawa and 2 more

Abstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Masataro TodaDepartment of Nephrology, Tokyo Saiseikai Central Hospital, Tokyo 108-0073, Japan.ORCID 0000-0001-6835-396X
Ayumi YoshifujiDepartment of Nephrology, Tokyo Saiseikai Central Hospital, Tokyo 108-0073, Japan.ORCID 0000-0001-8246-8675
Tetsuo NakayamaKitasato Institute for Life Sciences, Laboratory of Viral Infection, Kitasato University, Tokyo 108-8641, Japan.
Setsuko Mise-OmataDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Emi OyamaDepartment of Nephrology, Tokyo Saiseikai Central Hospital, Tokyo 108-0073, Japan.
Yoshifumi UwaminoDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
Motoaki KomatsuDepartment of Nephrology, Tokyo Saiseikai Central Hospital, Tokyo 108-0073, Japan.
Akihiko YoshimuraDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
Kan KikuchiDivision of Nephrology, Shimoochiai Clinic, Tokyo 161-0033, Japan.
Munekazu RyuzakiDepartment of Nephrology, Tokyo Saiseikai Central Hospital, Tokyo 108-0073, Japan.

Funding

Japan Agency for Medical Research and Development JP20fk0108283Japan Agency for Medical Research and Development JP20fk0108415Japan Agency for Medical Research and Development JP20fk0108452Japan Agency for Medical Research and Development JP21fk0108468Japan Agency for Medical Research and Development JP21fk0108469Japan Agency for Medical Research and Development JP21ym0126022Japan Agency for Medical Research and Development JP22gm1110009Japan Agency for Medical Research and Development JP22zf0127003Japan Society for the Promotion of Science 21H05044Japan Society for the Promotion of Science 22K1944
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) following primary immunization (breakthrough infection) has been reported in hemodialysis patients; however, their post-infection immune status remains unclear. We evaluated the humoral and cellular immunity of hemodialysis patients after breakthrough infection. Hemodialysis patients who had received primary immunization against COVID-19 at least six months prior to the study but developed mild/moderate COVID-19 before a booster dose (breakthrough infection group) and hemodialysis patients who were not infected with COVID-19 but received a booster dose (booster immunization group) were recruited. In both groups, SARS-CoV-2 antigen-specific cytokines and IgG levels were measured three weeks after infection or three weeks after receiving a booster dose. Memory T and B cells were also counted in the breakthrough infection group using flow cytometry three weeks after infection. Significantly higher SARS-CoV-2 antigen-specific IgG, IFN-γ, IL-5, TNF-α, and IL-6 levels occurred in the breakthrough infection group compared to the booster immunization group (

Indexed as

booster vaccinationbreakthrough infectionCOVID-19hemodialysis

Identifiers

PMID37515030
PMCPMC10384632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.