Evidence map›Paper›PMID 37515028›Full record

ArticleVaccines2023

Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to

Nathan M Ryan, Jessica A Hess, Erica J Robertson, Nancy Tricoche, Cheri Turner, Jenn Davis, Nikolai Petrovsky, Melissa Ferguson, William J Rinaldi, Valerie M Wong and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Nathan M RyanDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-5688-8331
Jessica A HessDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Erica J RobertsonDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Nancy TricocheLaboratory of Molecular Parasitology, Lindsey F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Cheri TurnerPAI Life Sciences Inc., Seattle, WA 98102, USA.
Jenn DavisPAI Life Sciences Inc., Seattle, WA 98102, USA.
Nikolai PetrovskyVaxine Pty Ltd., Bedford Park, Adelaide, SA 5042, Australia.ORCID 0000-0002-1580-5245
Melissa FergusonAlpha Genesis Inc., Yemassee, SC 29945, USA.
William J RinaldiAlpha Genesis Inc., Yemassee, SC 29945, USA.
Valerie M WongIDEXX BioAnalytics, West Sacramento, CA 95605, USA.
Ayako ShimadaDivision of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-9941-7660
Bin ZhanTexas Children's Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6884-9452
Maria Elena BottazziTexas Children's Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8429-0476
Benjamin L MakepeaceInstitute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK.ORCID 0000-0002-6100-6727
Sean A GrayPAI Life Sciences Inc., Seattle, WA 98102, USA.
Darrick CarterPAI Life Sciences Inc., Seattle, WA 98102, USA.ORCID 0000-0001-5901-3402
Sara LustigmanLaboratory of Molecular Parasitology, Lindsey F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
David AbrahamDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-3072-2541
Thomas Jefferson University · USPAI Life Sciences (United States) · USAlpha Genesis (United States) · USBaylor College of Medicine · USNew York Blood Center · USIDEXX Laboratories (United States) · USUniversity of Liverpool · GBVaxine (Australia) · AU

Funding

The development of a recombinant vaccine against human onchocerciasisR01AI078314 · NIAID · NEW YORK BLOOD CENTER · PI LUSTIGMAN, SARA · 2009 to 2021
$7.0M
Novel vaccine adjuvants to counter bioterrorist threatsU01AI061142 · NIAID · FLINDERS UNIVERSITY OF SOUTH AUSTRALIA · PI PETROVSKY, NIKOLAI · 2005 to 2009
$3.5M
Phase II - Development of a Prophylactic Onchocerciasis Vaccine75N93019C00028 · NIAID · PAI LIFE SCIENCES, INC. · PI CARTER, DARRICK · 2019 to 2019
$3.0M
NIAID NIH HHS 75N93019C00028NIAID NIH HHS R01 AI078314NIAID NIH HHS U01 AI061142
6 · The paper itself

Abstract

Onchocerciasis remains a debilitating neglected tropical disease. Due to the many challenges of current control methods, an effective vaccine against the causative agent

Indexed as

adjuvantAdvaxdurabilityfusion proteinmicenon-human primatesOnchocerca volvuluspassive immunizationriver blindnessvaccine

Identifiers

PMID37515028
PMCPMC10385774
OpenAlexW4383552062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.