Evidence map›Paper›PMID 37515009›Full record

ArticleVaccines2023

Influence of SARS-CoV-2 mRNA Vaccine Booster among Cancer Patients on Active Treatment Previously Immunized with Inactivated versus mRNA Vaccines: A Prospective Cohort Study.

Sebastián Mondaca, Benjamín Walbaum, Nicole Le Corre, Marcela Ferrés, Alejandro Valdés, Constanza Martínez-Valdebenito, Cinthya Ruiz-Tagle, Patricia Macanas-Pirard, Patricio Ross, Betzabé Cisternas and 14 more

Abstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Impact of COVID-19 vaccination on cancer patients: safety, efficacy, and long-term effects.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Sebastián MondacaDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Benjamín WalbaumDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.ORCID 0000-0003-2314-5360
Nicole Le CorreLaboratorio de Infectología y Virología Molecular, Red de Salud UC Christus, Santiago 8330024, Chile.
Marcela FerrésLaboratorio de Infectología y Virología Molecular, Red de Salud UC Christus, Santiago 8330024, Chile.
Alejandro ValdésDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Constanza Martínez-ValdebenitoLaboratorio de Infectología y Virología Molecular, Red de Salud UC Christus, Santiago 8330024, Chile.ORCID 0000-0002-2836-9817
Cinthya Ruiz-TagleDepartamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.ORCID 0000-0002-4712-3302
Patricia Macanas-PirardDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Patricio RossDepartamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.ORCID 0000-0002-8867-1970
Betzabé CisternasInstituto de Cáncer, Red de Salud UC-Christus, Santiago 8330032, Chile.
Patricia PérezInstituto de Cáncer, Red de Salud UC-Christus, Santiago 8330032, Chile.
Olivia CabreraInstituto de Cáncer, Red de Salud UC-Christus, Santiago 8330032, Chile.
Valentina CerdaInstituto de Cáncer, Red de Salud UC-Christus, Santiago 8330032, Chile.
Ivana OrmazábalEscuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Aldo BarreraLaboratorio de Infectología y Virología Molecular, Red de Salud UC Christus, Santiago 8330024, Chile.
María E PradoEscuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
María I VenegasEscuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Silvia PalmaInstituto de Cáncer, Red de Salud UC-Christus, Santiago 8330032, Chile.
Richard BroekhuizenDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Alexis M KalergisMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.ORCID 0000-0001-7622-5263
Susan M BuenoMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.ORCID 0000-0002-7551-8088
Manuel A EspinozaCenter for Cancer Prevention and Control, CECAN, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
M Elvira BalcellsDepartamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.
Bruno NerviDepartamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile.ORCID 0000-0002-3016-7261

Funding

Agencia Nacional de Investigación y Desarrollo 152220002Agencia Nacional de Investigación y Desarrollo 3220310
6 · The paper itself

Abstract

Cancer patients on chemotherapy have a lower immune response to SARS-CoV-2 vaccines. Therefore, through a prospective cohort study of patients with solid tumors receiving chemotherapy, we aimed to determine the immunogenicity of an mRNA vaccine booster (BNT162b2) among patients previously immunized with an inactivated (CoronaVac) or homologous (BNT162b2) SARS-CoV-2 vaccine. The primary outcome was the proportion of patients with anti-SARS-CoV-2 neutralizing antibody (NAb) seropositivity at 8-12 weeks post-booster. The secondary end points included IgG antibody (TAb) seropositivity and specific T-cell responses. A total of 109 patients were included. Eighty-four (77%) had heterologous vaccine schedules (two doses of CoronaVac followed by the BNT162b2 booster) and twenty-five had (23%) homologous vaccine schedules (three doses of BNT162b2). IgG antibody positivity for the homologous and heterologous regimen were 100% and 96% (

Indexed as

BNT162b2cancerchemotherapyCoronaVacCOVID-19SARS-CoV-2vaccinevaccine immunogenicity

Identifiers

PMID37515009
PMCPMC10384024

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.