Evidence map›Paper›PMID 37514960›Full record

ArticleVaccines2023

Differential Genome Replication of a Unique Single-Amino-Acid Mutation in the Adenovirus-4 Component of the Live Oral Adenovirus Type 4 and Type 7 Vaccine.

Natalie D Collins, Shannon Beaty, Elana Wallace, Yuanzhang Li, Mark Sanborn, Yu Yang, Anima Adhikari, Paul Shabram, Kelly Warfield, Nicos Karasavvas and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Natalie D CollinsWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-8011-9751
Shannon BeatyEmergent BioSolutions, Inc., Gaithersburg, MD 20879, USA.
Elana WallaceWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Yuanzhang LiWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Mark SanbornWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Yu YangWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Anima AdhikariWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Paul ShabramEmergent BioSolutions, Inc., Gaithersburg, MD 20879, USA.
Kelly WarfieldEmergent BioSolutions, Inc., Gaithersburg, MD 20879, USA.ORCID 0000-0003-1866-5388
Nicos KarasavvasWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Robert A KuschnerWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Jun HangWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-6597-7045
Walter Reed Army Institute of Research · USEmergent BioSolutions (United States) · US

Funding

Office of the Secretary of Defense W81XWH-17-2-0074United States Army Medical Research and Development Command W81XWH-16-C-0055
6 · The paper itself

Abstract

The FDA-approved Adenovirus Type 4 and Type 7 Vaccine, Live, Oral is highly effective and essential in preventing acute respiratory diseases (ARDs) in U.S. military recruits. Our study revealed the presence of a previously undetected mutation, not found in the wild-type human adenovirus type 4 (HAdV-4) component of the licensed vaccine, which contains an amino acid substitution (P388T) in the pre-terminal protein (pTP). This study demonstrated that replication of the T388 HAdV-4 vaccine mutant virus is favored over the wild type in WI-38 cells, the cell type utilized in vaccine manufacturing. However, results from serial human stool specimens of vaccine recipients support differential genome replication in the gastrointestinal tract (GI), demonstrated by the steady decline of the percentage of mutant T388 vaccine virus. Since vaccine efficacy depends upon GI replication and the subsequent immune response, the mutation can potentially impact vaccine efficacy.

Indexed as

adenovirusDNA virusHAdV-4mutationpre-terminal proteinreplicationvaccine

Identifiers

PMID37514960
PMCPMC10385111
OpenAlexW4382137158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.