Evidence map›Paper›PMID 37514084›Full record

ArticlePharmaceutics2023

Whole Yeast Vaccine Displaying ZIKV B and T Cell Epitopes Induces Cellular Immune Responses in the Murine Model.

Anna Jéssica Duarte Silva, André Luiz Santos de Jesus, Lígia Rosa Sales Leal, Larissa Silva de Macêdo, Bárbara Rafaela da Silva Barros, Georon Ferreira de Sousa, Simone da Paz Leôncio Alves, Lindomar José Pena, Cristiane Moutinho Lagos de Melo, Antonio Carlos de Freitas

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Anna Jéssica Duarte SilvaLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-8341-7877
André Luiz Santos de JesusFederal Institute of Mato Grosso, Lucas do Rio Verde 78455-000, Brazil.ORCID 0000-0003-2335-5712
Lígia Rosa Sales LealLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-4453-8238
Larissa Silva de MacêdoLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0003-1660-4901
Bárbara Rafaela da Silva BarrosDepartment of Antibiotics, Federal University of Pernambuco, Recife 50670-901, Brazil.
Georon Ferreira de SousaDepartment of Antibiotics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0001-8780-202X
Simone da Paz Leôncio AlvesDepartment of Pharmacy, Federal University of Pernambuco, Recife 50670-901, Brazil.
Lindomar José PenaDepartment of Virology and Experimental Therapy, Instituto Aggeu Magalhães, Oswaldo Cruz Foundation, Recife 50670-901, Brazil.
Cristiane Moutinho Lagos de MeloDepartment of Antibiotics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-8831-0163
Antonio Carlos de FreitasLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-4957-9549
Universidade Federal de Pernambuco · BRFundação Oswaldo Cruz · BRInstituto Federal de Educação, Ciência e Tecnologia de Mato Grosso · BR

Funding

Foundation for the Support of Science and Technology of Pernambuco APQ-1482-2.02/22National Council for Scientific and Technological Development 440315/2022-0National Council for Scientific and Technological Development 88887.507421/ 2020-00
6 · The paper itself

Abstract

Improving antigen presentation is crucial for the success of immunization strategies. Yeasts are classically used as biofactories to produce recombinant proteins and are efficient vehicles for antigen delivery, in addition to their adjuvant properties. Despite the absence of epidemic outbreaks, several vaccine approaches continue to be developed for Zika virus infection. The development of these prophylactic strategies is fundamental given the severity of clinical manifestations, mainly due to viral neurotropism. The present study aimed to evaluate in vivo the immune response induced by

Indexed as

multi-epitopeP. pastorisyeast-based vaccinesyeast surface display

Identifiers

PMID37514084
PMCPMC10385271
OpenAlexW4383551366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.