Evidence map›Paper›PMID 37514055›Full record

ArticlePharmaceutics2023

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against

Anand Chakroborty, Deiniol R Pritchard, Marc E Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino and 7 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anand ChakrobortyThe Department of Life Sciences (DLS), Aberystwyth University, Aberystwyth SY23 3DA, UK.ORCID 0000-0003-4987-2646
Deiniol R PritchardNaturiol Bangor Ltd., MSParc, Gaerwen, Anglesey LL60 6AG, UK.
Marc E BouillonSchool of Natural Sciences, Bangor University, Bangor LL57 2UW, UK.
Anna CerviNaturiol Bangor Ltd., MSParc, Gaerwen, Anglesey LL60 6AG, UK.
Rolf KraehenbuehlSchool of Natural Sciences, Bangor University, Bangor LL57 2UW, UK.
Charlotte WildRidgeway Research Limited, Park Farm Buildings, Park Lane, St. Briavels, Gloucestershire GL15 6QX, UK.
Caroline FennRidgeway Research Limited, Park Farm Buildings, Park Lane, St. Briavels, Gloucestershire GL15 6QX, UK.
Peter HoldsworthRidgeway Research Limited, Park Farm Buildings, Park Lane, St. Briavels, Gloucestershire GL15 6QX, UK.ORCID 0009-0007-9173-5369
Colin CapnerRidgeway Research Limited, Park Farm Buildings, Park Lane, St. Briavels, Gloucestershire GL15 6QX, UK.ORCID 0000-0001-7179-3755
Gilda PadalinoThe Department of Life Sciences (DLS), Aberystwyth University, Aberystwyth SY23 3DA, UK.
Josephine E Forde-ThomasThe Department of Life Sciences (DLS), Aberystwyth University, Aberystwyth SY23 3DA, UK.ORCID 0000-0002-7202-3565
Joseph PayneRidgeway Research Limited, Park Farm Buildings, Park Lane, St. Briavels, Gloucestershire GL15 6QX, UK.
Brendan G SmithBimeda UK, Bryn Cefni Industrial Estate, Unit 2A, Llangefni LL77 7XA, UK.
Maggie FisherRidgeway Research Limited, Park Farm Buildings, Park Lane, St. Briavels, Gloucestershire GL15 6QX, UK.
Martina LahmannSchool of Natural Sciences, Bangor University, Bangor LL57 2UW, UK.ORCID 0000-0002-8513-1952
Mark S BairdNaturiol Bangor Ltd., MSParc, Gaerwen, Anglesey LL60 6AG, UK.ORCID 0000-0001-5340-8745
Karl F HoffmannThe Department of Life Sciences (DLS), Aberystwyth University, Aberystwyth SY23 3DA, UK.

Funding

Innovate UK 102101
6 · The paper itself

Abstract

Infection with

Indexed as

anthelmintic drug discoveryFasciola hepaticaHedera helixsaponins and hederagenin

Identifiers

PMID37514055
PMCPMC10385850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.