Evidence map›Paper›PMID 37513982›Full record

ArticlePharmaceutics2023

An Innovative Polymeric Platform for Controlled and Localized Drug Delivery.

Monica Elbjorn, Jacob Provencio, Paige Phillips, Javier Sainz, Noah Harrison, David Di Rocco, Ada Jaramillo, Priya Jain, Alejandro Lozano, R Lyle Hood

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Monica ElbjornDepartment of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Jacob ProvencioDepartment of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Paige PhillipsDepartment of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Javier SainzDepartment of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Noah HarrisonDepartment of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
David Di RoccoDepartment of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Ada JaramilloDepartment of Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Priya JainDepartment of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Alejandro LozanoDepartment of Obstetrics & Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
R Lyle HoodDepartment of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0003-0478-2065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision medicine aims to optimize pharmacological treatments by considering patients' genetic, phenotypic, and environmental factors, enabling dosages personalized to the individual. To address challenges associated with oral and injectable administration approaches, implantable drug delivery systems have been developed. These systems overcome issues like patient adherence, bioavailability, and first-pass metabolism. Utilizing new combinations of biodegradable polymers, the proposed solution, a Polymeric Controlled Release System (PCRS), allows minimally invasive placement and controlled drug administration over several weeks. This study's objective was to show that the PCRS exhibits a linear biphasic controlled release profile, which would indicate potential as an effective treatment vehicle for cervical malignancies. An injection mold technique was developed for batch manufacturing of devices, and in vitro experiments demonstrated that the device's geometry and surface area could be varied to achieve various drug release profiles. This study's results motivate additional development of the PCRS to treat cervical cancer, as well as other malignancies, such as lung, testicular, and ovarian cancers.

Indexed as

cervical cancerpolycaprolactonepoly-lactic acidpolymer castingpolymeric drug deliveryrhodamine Btargeted drug delivery system

Identifiers

PMID37513982
PMCPMC10385353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.