ReviewPharmaceutics2023
Impact of Intensive Glycemic Treatment on Diabetes Complications-A Systematic Review.
Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Impact of integrative therapies on glycemic control in type 1 diabetes: a systematic review and global research landscape.Frontiers in clinical diabetes and healthcare · 2026Pooled it
- Efficacy of Community-based Interventions in Reducing HbA1c Levels Among Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Recent Studies Conducted in Developing Countries.Journal of primary care & community healthPooled it
- Pharmacological characteristics of once-weekly insulin icodec in Japanese individuals with type 1 diabetes.Journal of diabetes investigation · 2025Trial
- The cognitive consequences of hypoglycemia in diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Effect of the initial combination approach vs initial monotherapy approach on 1-year trajectories of adherence in drug-naive patients with type 2 diabetes.Journal of managed care & specialty pharmacy · 2026Article
- Self-Care Practices and Their Association with Glycemic Indices among Patients with Diabetes Mellitus Attending a rural Health Care Facility in Karnataka.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Article
- Effects of a Nurse-Led Diabetes Perception Intervention Delivered via a Mobile Messaging Platform (LINE) on Glycemic Control and Patient Outcomes Among Adults with Diabetes and Poorly Controlled Glucose: A Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2026Article
- A Rat Model Mimicking Treatment-Induced Painful Diabetic Neuropathy Following Experimental Rapid Weight Loss.Journal of pain research · 2026Article
- Surgical Outcomes of Cataract Surgery Following Rapid Glycemic Control During Preoperative Period.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Missed opportunities in diabetes care: unraveling therapeutic inertia and its predictors in resource-limited settings.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Diabetic Complication Profiles and Associated Risk Factors: A Comprehensive Analysis from Two Public Hospitals in the Najran Region, Southern Saudi Arabia.Medicina (Kaunas, Lithuania) · 2025Article
- Treatment-induced neuropathy of diabetes complicated by orthostatic hypotension.Endocrinology, diabetes & metabolism case reports · 2025Article
- Does Improvement of Glycemic Control Cause Acute Charcot Foot in Patients with Diabetes?Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2025Review
- Article
- Glycemic control and associated factors in patients with type 2 diabetes in Southwest Ethiopia: a prospective observational study.BMC endocrine disorders · 2024Observational
- Correlation between serum advanced glycation end-products and vascular complications in patient with type 2 diabetes.Scientific reports · 2024Article
- Food-Derived Up-Regulators and Activators of Angiotensin Converting Enzyme 2: A Review.Journal of agricultural and food chemistry · 2024Review
- Review
- Acute worsening of microvascular complications of diabetes mellitus during rapid glycemic control: The pathobiology and therapeutic implications.World journal of diabetes · 2024Article
- Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis,Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes complications can be related to the long duration of the disease or chronic hyperglycemia. The follow-up of diabetic patients is based on the control of chronic hyperglycemia, although this correction, if obtained rapidly in people living with severe chronic hyperglycemia, can paradoxically interfere with the disease or even induce complications. We reviewed the literature describing the impact of the rapid and intense treatment of hyperglycemia on diabetic complications. The literature review showed that worsening complications occurred significantly in diabetic microangiopathy with the onset of specific neuropathy induced by the correction of diabetes. The results for macroangiopathy were somewhat mixed with the intensive and rapid correction of chronic hyperglycemia having a neutral impact on stroke and myocardial infarction but a significant increase in cardiovascular mortality. The management of diabetes has now entered a new era with new therapeutic molecules, such as gliflozin for patients living with type 2 diabetes, or hybrid insulin delivery systems for patients with insulin-treated diabetes. Our manuscript provides evidence in support of these personalized and progressive algorithms for the control of chronic hyperglycemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.