Evidence map›Paper›PMID 37513794›Full record

ReviewPathogens (Basel, Switzerland)2023

Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies.

Diana Emilia Martínez-Fernández, David Fernández-Quezada, Fidel Antonio Guadalupe Casillas-Muñoz, Francisco Josué Carrillo-Ballesteros, Ana Maria Ortega-Prieto, Jose M Jimenez-Guardeño, Jose Angel Regla-Nava

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Review
  3. Therapeutic Innovations for Monkeypox Inhibition.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Mpox and cancer: Dual dangers.Medical journal, Armed Forces India · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Monkeypox Virus and Pregnancy.Journal of medical virology · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Diana Emilia Martínez-FernándezTransdisciplinary Institute of Research and Services (ITRANS), University of Guadalajara, Zapopan 45150, Mexico.ORCID 0000-0002-3640-4870
David Fernández-QuezadaDepartment of Neurosciences, University Center for Health Science (CUCS), University of Guadalajara, Guadalajara 44340, Mexico.
Fidel Antonio Guadalupe Casillas-MuñozTransdisciplinary Institute of Research and Services (ITRANS), University of Guadalajara, Zapopan 45150, Mexico.ORCID 0000-0003-1969-3516
Francisco Josué Carrillo-BallesterosTransdisciplinary Institute of Research and Services (ITRANS), University of Guadalajara, Zapopan 45150, Mexico.
Ana Maria Ortega-PrietoDepartment of Microbiology, University of Málaga, 29010 Málaga, Spain.ORCID 0000-0002-9023-0103
Jose M Jimenez-GuardeñoDepartment of Microbiology, University of Málaga, 29010 Málaga, Spain.ORCID 0000-0002-1726-8033
Jose Angel Regla-NavaDepartment of Microbiology and Pathology, University Center for Health Science (CUCS), University of Guadalajara, Guadalajara 44340, Mexico.
Universidad de Guadalajara · MXInstituto de Investigación Biomédica de Málaga · ES

Funding

J.M.J.-G. received support from the Grant RYC2021-031227-I funded by the MCIN/AEI/10.13039/501100011033 and the European Union "NextGenerationEU"/PRTR and the Grant Proyecto19 funded by the University of Málaga Plan Propio. RYC2021-031227-I
6 · The paper itself

Abstract

Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular-pustular skin lesions. However, the differential diagnosis between smallpox and monkeypox is that smallpox does not cause lymphadenopathy but monkeypox generates swelling in the lymph nodes. Since the eradication of smallpox, MPXV has been identified as the most common Orthopoxvirus to cause human disease. Despite MPXV being endemic to certain regions of Africa, the current MPXV outbreak, which began in early 2022, has spread to numerous countries worldwide, raising global concern. As of the end of May 2023, over 87,545 cases and 141 deaths have been reported, with most cases identified in non-endemic countries, primarily due to human-to-human transmission. To better understand this emerging threat, this review presents an overview of key aspects of MPXV infection, including its animal reservoirs, modes of transmission, animal models, epidemiology, clinical and immunological features, diagnosis, treatments, vaccines, and prevention strategies. The material presented here provides a comprehensive understanding of MPXV as a disease, while emphasizing the significance and unique characteristics of the 2022 outbreak. This offers valuable information that can inform future research and aid in the development of effective interventions.

Indexed as

monkeypox (MPX)Orthopoxviruspublic health emergencysmallpoxzoonotic disease

Identifiers

PMID37513794
PMCPMC10384102
OpenAlexW4384662071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.