Evidence map›Paper›PMID 37513785›Full record

ArticlePathogens (Basel, Switzerland)2023

Rates of Seroprotection against Vaccine-Preventable Infectious Diseases in HIV-Exposed and -Unexposed Malawian Infants.

Silvia Baroncelli, Clementina Maria Galluzzo, Stefano Orlando, Maria Franca Pirillo, Richard Luhanga, Robert Mphwere, Thom Kavalo, Roberta Amici, Marco Floridia, Mauro Andreotti and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Silvia BaroncelliNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Clementina Maria GalluzzoNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Stefano OrlandoDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Maria Franca PirilloNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Richard LuhangaDREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre 312200, Malawi.
Robert MphwereDREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre 312200, Malawi.
Thom KavaloDREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre 312200, Malawi.
Roberta AmiciNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Marco FloridiaNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0003-3971-0141
Mauro AndreottiNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0001-5168-8624
Fausto CiccacciUniCamillus, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.
Paola ScarcellaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-3319-7925
Maria Cristina MarazziDREAM Program, Community of S. Egidio, Piazza Sant'Egidio 3, 00153 Rome, Italy.ORCID 0000-0003-2031-5213
Marina GiulianoNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.ORCID 0000-0003-2789-7797
Istituto Superiore di Sanità · ITCommunity Living · USUniversity of Rome Tor Vergata · ITPresidio Ospedaliero · ITSaint Camillus International University of Health and Medical Sciences · IT

Funding

Italian Agency for Cooperation and Development through the Global Fund 5% Initiative AID 011141/03/04Italy Independent Activity in the scope of EDCTP2 PSIA 2019-2072
6 · The paper itself

Abstract

backgroundThe evaluation of seroprotection rates against vaccine-preventable infectious diseases allows for the identification of risk populations. HIV-exposed infants, even if not infected with HIV, have higher morbidity and mortality in comparison to unexposed counterparts. The aim of this study was to compare the specific IgG levels against

methodsBlood samples from 62 infants, 49 HIV-exposed, uninfected (HEU), and born to women living with HIV and 13 HIV-unexposed and uninfected (HUU), were collected at 6 months, and specific IgG levels were determined using ELISA tests.

resultsThe antibody levels against HiB, HBV, and Spn were similar in the two groups. At six months, all HUU infants and 81.6% of HEU infants showed seroprotective levels against HiB, while a percentage of protection varying from 80.6 to 84.6% was observed for HBV and Spn regardless of HIV exposure. Only 59.2% of HEU and 69.2% of HUU infants showed antibody protection against all three pathogens.

conclusionsThese results indicate similar rates of seroprotection among HEU and HUU infants but also suggest that a consistent fraction of infants received incomplete vaccinations. Strategies to enforce participation in immunization programs in Malawi should be a health priority.

Indexed as

AfricaHaemophilus influenzae type Bhepatitis BHIV in utero-expositionIgG protective levelsinfantsStreptococcus pneumoniaevaccine-preventable diseases

Identifiers

PMID37513785
PMCPMC10383556
OpenAlexW4384525802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.