Evidence map›Paper›PMID 37513779›Full record

ArticlePathogens (Basel, Switzerland)2023

Pulmonary Co-Infections Detected Premortem Underestimate Postmortem Findings in a COVID-19 Autopsy Case Series.

Andrew P Platt, Benjamin T Bradley, Nadia Nasir, Sydney R Stein, Sabrina C Ramelli, Marcos J Ramos-Benitez, James M Dickey, Madeleine Purcell, Shreya Singireddy, Nicole Hays and 20 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 7 institutions in 2 countries.

Andrew P PlattEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Benjamin T BradleyDepartment of Pathology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8064-9314
Nadia NasirLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sydney R SteinEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Sabrina C RamelliLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-5428-2814
Marcos J Ramos-BenitezEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
James M DickeyEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Madeleine PurcellUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Shreya SingireddyUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Nicole HaysUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jocelyn WuUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Katherine RajaUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-8108-5904
Ryan CurtoUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Stephen J SalipanteDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Claire ChisholmDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Stephanie CarnesAmerican Esoteric Laboratories, Memphis, TN 38134, USA.
Desiree A MarshallDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Brad T CooksonDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Kevin M VannellaEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Ronson J MadathilDepartment of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Shahabuddin SoherwardiHospitalist Department, TidalHealth Peninsula Regional, Salisbury, MD 21801, USA.ORCID 0000-0003-3370-6192
Michael T McCurdyUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-5319-0475
Kapil K SahariaInstitute of Human Virology, Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-5116-0042
Joseph RabinR Adams Cowley Shock Trauma Center, Department of Surgery and Program in Trauma, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Nih Covid-Autopsy Consortium
Alison GrazioliR Adams Cowley Shock Trauma Center, Department of Medicine and Program in Trauma, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
David E KleinerLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Stephen M HewittLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Joshua A LiebermanDepartment of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.ORCID 0000-0002-0376-1337
Daniel S ChertowEmerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-1675-1728
University of Maryland, Baltimore · USNational Institute of Allergy and Infectious Diseases · USUniversity of Washington Medical Center · USNational Institutes of Health · USPeninsula Regional Medical Center · USPonce Health Sciences University · PRUniversity of Utah · US

Funding

Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
NCI NIH HHS n/a
6 · The paper itself

Abstract

Bacterial and fungal co-infections are reported complications of coronavirus disease 2019 (COVID-19) in critically ill patients but may go unrecognized premortem due to diagnostic limitations. We compared the premortem with the postmortem detection of pulmonary co-infections in 55 fatal COVID-19 cases from March 2020 to March 2021. The concordance in the premortem versus the postmortem diagnoses and the pathogen identification were evaluated. Premortem pulmonary co-infections were extracted from medical charts while applying standard diagnostic definitions. Postmortem co-infection was defined by compatible lung histopathology with or without the detection of an organism in tissue by bacterial or fungal staining, or polymerase chain reaction (PCR) with broad-range bacterial and fungal primers. Pulmonary co-infection was detected premortem in significantly fewer cases (15/55, 27%) than were detected postmortem (36/55, 65%;

Indexed as

autopsyco-infectionCOVID-19invasive fungal infectionsnosocomial infectionspneumonia

Identifiers

PMID37513779
PMCPMC10383307
OpenAlexW4384202537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.